Elucidation of regulatory mechanisms of central nervous system functions by ceramide kinase
| Project/Area Number |
26460060
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | セラミドキナーゼ / セラミド-1-リン酸 / 神経突起 / 神経伝達物質 / PC12細胞 |
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| Outline of Final Research Achievements |
Ceramide kinase produces the bioactive lipid ceramide-1-phosphate. In this study, we determined the role of ceramide kinse on functions of central nervous system. We showed that 1) ceramide kinase regulates the formation of filopodia, 2) NGF induces the formation of ceramide-1-phoshate in PC12 cells, 3) ceramide kinase regulates the release of neurotransmitter.
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Report
(4 results)
Research Products
(44 results)
