Researches on regulation of intractable atopic disease by targeting IL-33
| Project/Area Number |
26460108
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Pharmacology in pharmacy
|
|---|
| Research Institution | Setsunan University |
|---|
Principal Investigator |
Nabe Takeshi 摂南大学, 薬学部, 教授 (40228078)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
福井 裕行 徳島大学, 大学院医歯薬学研究部(薬学系), 特任教授 (90112052)
水谷 暢明 神戸薬科大学, 薬学部, 准教授 (90340447)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | IL-33 / 喘息 / アトピー / 制御性T細胞 / 抗アレルギー薬 |
|---|
| Outline of Final Research Achievements |
In the pathogenesis of intractable asthma, IL-33 has been known to be a key molecule bridging between the innate and acquired immune systems. In this study, we analyzed mechanisms underlying IL-33 production, and immunopharmacological modulation of IL-33. Allergic IL-33 production induced by an intratracheal antigen challenge in sensitized mice was mediated by neither mast cells nor Th2 cells. The administered antigen formed an immune complex with the antigen-specific IgG antibody, followed by incorporation into the alveolar macrophages through the cellular suface FcgRII/III, leading to the IL-33 production in the lung. The IL-33 production was sensitive to steroid anti-inflammatory drug treatment. On the other hand, as a new method for regulation of allergy, adoptive transfer of in vitro-differentiated IL-10-producing T cells effectively suppressed asthmatic responses in mice in vivo.
|
Report
(4 results)
Research Products
(34 results)
-
-
-
-
-
-
-
-
[Journal Article] Production of interleukin (IL)-33 in the lungs during multiple antigen challenge-induced airway inflammation in mice, and its modulation by a glucocorticoid2015
Author(s)
Takeshi Nabe, Hiroki Wakamori, Chihiro Yano, Ayumi Nishiguchi, Rino Yuasa, Hitomi Kido, Yusaku Tomiyama, Ayumi Tomoda, Haruka Kida, Anna Takiguchi, Masaya Matsuda, Keiichi Ishihara, Satoshi Akiba, Susumu Ohya, Hiroyuki Fukui, Nobuaki Mizutani, Shin Yoshino
-
Journal Title
European Journal of Pharmacology
Volume: 757
Pages: 34-41
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
