Analysis of the mechanism of anti-oxidative and anti-inflammatory actions of D-allose
Project/Area Number |
26460123
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Natural medicines
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Research Institution | Kagawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
山口 文徳 香川大学, 医学部, 准教授 (40271085)
神鳥 和代 香川大学, 医学部, 助教 (40457338)
董 有毅 香川大学, 医学部, 助教 (90457341)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | D-allose / rare sugar / anti-oxidant / MAPK / D-アロース / 抗酸化作用 / 抗炎症作用 / マクロファージ / トランスポーター / 希少糖 |
Outline of Final Research Achievements |
D-allose, one of rare sugars, has anti-oxidative action, and is expected to have action to carbohydrate and lipid metabolism. By metabolome analysis, we found a total reducing potential increased significantly in cells and tissues. We also found that D-allose enhanced TXNIP (Thioredoxin Interacting Protein) expression. TXNIP expression and its phosphorylation were regulated by MAPK signaling system. By autoradiographic analysis of D-allose, we found that D-allose goes through blood brain barrier, and that D-allose is safe as a food material. We therefore could established the foundation of application of D-allose.
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Report
(4 results)
Research Products
(21 results)
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[Journal Article] d-Allose Attenuates Overexpression of Inflammatory Cytokines after Cerebral Ischemia/Reperfusion Injury in Gerbil.2016
Author(s)
Shinohara N, Nakamura T, Abe Y, Hifumi T, Kawakita K, Shinomiya A, Tamiya T, Tokuda M, Keep RF, Yamamoto T, Kuroda Y.
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Journal Title
J Stroke Cerebrovasc Dis.
Volume: 25
Issue: 9
Pages: 2184-2188
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Rare sugar D-psicose prevents progression and development of diabetes in T2DM model Otsuka Long-Evans Tokushima Fatty rats.2015
Author(s)
Hossain A, Yamaguchi F, Hirose K, Matsunaga T, Sui L, Hirata Y, Noguchi C, Katagi A, Kamitori K, Dong Y, Tsukamoto I, Tokuda M.
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Journal Title
Drug Des Devel Ther
Volume: 9
Pages: 525-535
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose.2014
Author(s)
Tsukamoto I, Hossain A, Yamaguchi F, Hirata Y, Dong Y, Kamitori K, Sui L, Nonaka M, Ueno M, Nishimoto K, Suda H, Morimoto K, Shimonishi T, Saito M, Song T, Konishi R, Tokuda M
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Journal Title
Drug Des Devel Ther
Volume: 17
Pages: 1955-1964
DOI
Related Report
Peer Reviewed
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