Design of inhibitors of amyloid beta aggregation and BACE1 for conquering Alzheimer's disease
| Project/Area Number |
26460163
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Konan University (2016-2017)
Kobe Pharmaceutical University (2014-2015) |
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Principal Investigator |
HAMADA Yoshio 甲南大学, フロンティアサイエンス研究科, 特別研究員 (70424968)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | アルツハイマー病 / BACE1 / β-セクレターゼ / アミロイドβ / 凝集阻害剤 / BACE1阻害剤 / β‐セクレターゼ / 酵素阻害剤 / ドッキング計算 / 創薬 / 凝集祖愛剤 / アミロイドβペプチド |
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| Outline of Final Research Achievements |
The increase of dementia patients is a big issue for Japan as it faces a rapidly against society. To conquer Alzheimer's disease, this reaearch aimed the development of inhibitors of amyloid beta aggregation and BACE1. We designed and synthesized a series of small-sized BACE1 inhibitors with a thiadiazole moiety. These compounds with improved membrane permeability appear to have promise as drug candidates. And we synthesized aggregation inhibitors. These aggregation inhibitors could recognized a specific Abeta conformer, and are expected to use a research tool for pathogenic mechanism analysis.
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Report
(5 results)
Research Products
(48 results)
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[Journal Article] DNA G-wire formation using an artificial peptide is controlled by protease activity2017
Author(s)
Usui, K., Okada, A., Sakashita, S., Shimooka, M., Tsuruoka, T., Nakano, S., Miyoshi, D., Mashima, T., Katahira, M., Hamada, Y.
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Journal Title
Molecules
Volume: 22
Issue: 11
Pages: 1991-1991
DOI
NAID
Related Report
Peer Reviewed / Open Access
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