Analysis on mechanism of hippocampus-dependent long-term memory via theanine-mediated enhancement of memory
| Project/Area Number |
26460172
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
Tamano Haruna 静岡県立大学, 薬学部, 特任講師 (30322697)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 記憶 / LTP / 亜鉛 / 海馬 / テアニン / NMDA受容体 / non-NMDA受容体 / 物体認識記憶 / 海馬歯状回 |
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| Outline of Final Research Achievements |
The present study demonstrated that intake of theanine, a major component of amino acids in green tea, enhances hippocampal neurogenesis, which is related to long-term memory, followed by enhancement of hippocampal long-term potentiation (LTP), a cellular mechanism of memory. On the other hand, the present study revealed that intracellular zinc signaling in the glutamatergic synapses in the hippocampus is necesarry for not only memory acquisition but also memory retention via LTP induction and its maintenance. And, the present study indicates that increase in Zn2+ influx into dentate granule cells through AMPA receptors, a subtype of glutamate receptor, loses maintained LTP and memory. Regulation of Zn2+ influx into dentate granule cells is more critical for not only memory acquisition but also memory retention than that of Ca2+ influx.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Preventive effect of 3,5-dihydroxy-4-methoxybenzyl alcohol and zinc, Pacific oyster components, on glutamatergic neuron activity in the hippocampusBiol. Bul.2015
Author(s)
Haruna Tamano, Yukina Shakushi, Mitsugu Watanabe, Kazumi Ohashi, Chihiro Uematsu, Tadamune Otsubo, Kiyoshi Ikeda, and Atsushi Takeda
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Journal Title
Biol. Bul.
Volume: 229
Pages: 282-288
Related Report
Peer Reviewed
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