Neuroprotective mechanism of carnosine against zinc-induced neurotoxicity: a possible drug for vascular dementia
| Project/Area Number |
26460177
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Musashino University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
水野 大 山形大学, 医学部, 准教授 (70380061)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経毒性 / 亜鉛 / 銅 / カルシウム / 小胞体ストレス / アルツハイマー病 / プリオン病 / 老年性認知症 / 神経細胞死 / カルシウムホメオスタシス / ARDS / 肺疾患 / 抗酸化 / 運動能力 / アポトーシス / HPLC / carnosine / ER stress / Zn / amyloid / anserine / dementia / Alzheimer |
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| Outline of Final Research Achievements |
Carnosine (β-alanyl histidine) is a small dipeptide abundantly present in the muscloes and brains. Carnosine has numerous beneficial characteristics, including the maintenance of the acid-base balance, antioxidant, metal chelating, anti-crosslinking, and anti-glycation activities. We investigated the neuroprotective effects of carnosine and the related compounds, and found that carnosine attenuated zinc-induced neurodegeneration, which plays central roles in the pathogenesis of vascular dementia. Furthermore, carnosine and its analogue anserine inhibited zinc-induced endoplasmic reticulum (ER)-stress, and attenuated the neurotoxicity induced by ER-stress inducers such as thapsigargin. We developed a convenient method to quantify the amount of carnosine using HPLC equipped with the carbon column, and investigated the amount of carnosine and anserine in various foods or in muscles of Thoroughbred horses. Our results are useful in the development of drugs for vascular dementia.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Protective and therapeutic effect of felodipine against bleomycin-induced pulmonary fibrosis in mice2017
Author(s)
Tanaka K, Niino T, Ishihara T, Sugizaki T, Takafuji A, Takayama T, Kanda Y, Tamura F, Kurotsu S, Kawahara M, Mizushima T
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Journal Title
Scientific Reports
Volume: 7
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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