| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
White adipose tissue (WAT) and brown adipose tissue (BAT) have distinct developmental origins and distinct functions of energy storage and heat production, respectively. We previously found that RXR agonist PA024 prevented high-fat diet-induced obesity and increased oxygen consumption in mice. In this study, we investigated the mechanism. We found that administration of PA024 to mice led to increases in brown fat-selective gene expression in WAT. PA024 was shown to have the ability to directly induce brown fat-gene expression in white preadipocytes. The same effect was also caused by other synthetic RXR agonists and tributyltin.
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