Objective evaluation of chemotherapy-induced peripheral neuropathy using quantitative pain measurement system

Research Project

Project/Area Number	26460230
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Medical pharmacy
Research Institution	Iwate Medical University
Principal Investigator	Sato Junya 岩手医科大学, 薬学部, 講師 (40616413)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000) Fiscal Year 2015: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000) Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords	がん化学療法 / 末梢神経障害 / 知覚痛覚定量分析装置 / パクリタキセル / 末梢神経障害質問票（PNQ） / 抗がん剤 / Pain vison / PAIN VISION / オキサリプラチン / 手足クーリング / ブシ末
Outline of Final Research Achievements	For an evaluation of peripheral neuropathy (CIPN) with the chemotherapy, objectivity may be poor because it is determined by the subjective expression of the patients．We attempted an objective evaluation of paclitaxel-induced CIPN using quantitative pain measurement system (Pain vison®).The pain degree (pain perception current value - smallest perception current level) ÷smallest perception current value×100) at the CIPN development by the medical professional evaluation (CTC-AE) was significantly decreased as compared to that of before chemotherapy initiation.Pain vision might become the noninvasive and convenient objective CIPN detection tool to supplement subjective CIPN evaluation.