1.Pharmacokinetic and pharmacodynamic analysis of anticoagulants in patients with total knee arthroplasty
| Project/Area Number |
26460237
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 個別投与 / 抗凝固薬 / 血栓予防 / 体内動態 / 個人差 / 最高血中濃度 / 静脈血栓塞栓症予防 / フォンダパリヌクス / エノキサパリン / エドキサバン / 人工膝関節置換術 / 静脈血栓塞栓症 / 出血 / 個体差発現要因 / 個別化治療 / 薬物動態 |
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| Outline of Final Research Achievements |
This study investigated to clarify the factors affecting the efficacy, adverse events, and pharmacokinetics of anti-coagulants, enoxaparin, fondaparinux and edoxaban in Japanese patients undergoing artificial total knee replacement surgery. We have revealed that the maximum plasma concentration of anti-coagulant may be a risk factor for subcutaneous hemorrhage and withdrawal of anti-coagulant. Population pharmacokinetic analysis showed that total clearance and volume of distribution of fondaparinux are affected by creatinine clearance and body weight, respectively.
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Report
(4 results)
Research Products
(10 results)
