| Project/Area Number |
26460248
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OTAGIRI Masaki 崇城大学, 薬学部, 教授 (80120145)
UEKAMA Kaneto 崇城大学, 薬学部, 特任教授 (90040328)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 酸化ストレス関連疾患 / 抗酸化作用 / 慢性腎不全 / キトサン / シクロデキストリン / アルブミン / 酸化ストレス / 多機能性多糖 / 多機能性 / ナノファイバー |
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| Outline of Final Research Achievements |
We investigated the effect of cyclodextrin (CD) and surface-deacetylated chitin nano-fibers (SDACNFs) on oxidative stress and related biochemical properties in chronic renal failure (CRF). In CRF model rats, CD and SDACNFs has a high antioxidant activity as well as the ability to exert reno-protective effects. From these results, we hypothesize that CD and SDACNFs reduces the levels of uremic toxins that induce the production of reactive oxygen species in the intestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in CRF. By using these characteristics, we prepared a gel starting from SDACNFs by utilizing electrostatic interactions with an anionic CD, sulfobutyl ether β-CD (SBE-β-CD). This elastic gel would be potentially useful, not only as an extended release gel with high antioxidant activity but also as a safe, non-toxic gel for the treatment of CRF.
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