Multifaceted antioxidant evaluation of medicine and functional food for chronic renal failure

• Project/Area Number: 26460248
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Sojo University
• Principal Investigator: ANRAKU Makoto 崇城大学, 薬学部, 准教授 (60398245)
• Co-Investigator(Renkei-kenkyūsha): OTAGIRI Masaki 崇城大学, 薬学部, 教授 (80120145) ; UEKAMA Kaneto 崇城大学, 薬学部, 特任教授 (90040328)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 酸化ストレス関連疾患 / 抗酸化作用 / 慢性腎不全 / キトサン / シクロデキストリン / アルブミン / 酸化ストレス / 多機能性多糖 / 多機能性 / ナノファイバー

Outline of Final Research Achievements

We investigated the effect of cyclodextrin (CD) and surface-deacetylated chitin nano-fibers (SDACNFs) on oxidative stress and related biochemical properties in chronic renal failure (CRF). In CRF model rats, CD and SDACNFs has a high antioxidant activity as well as the ability to exert reno-protective effects. From these results, we hypothesize that CD and SDACNFs reduces the levels of uremic toxins that induce the production of reactive oxygen species in the intestinal tract, thereby inhibiting the subsequent development of oxidative stress in the systemic circulation in CRF. By using these characteristics, we prepared a gel starting from SDACNFs by utilizing electrostatic interactions with an anionic CD, sulfobutyl ether β-CD (SBE-β-CD). This elastic gel would be potentially useful, not only as an extended release gel with high antioxidant activity but also as a safe, non-toxic gel for the treatment of CRF.

Research Products

• [Journal Article] An oral absorbent, surface-deacetylated chitin nano-fiber ameliorates renal injury and oxidative stress in 5/6 nephrectomized rats (2017)
  • Author(s): Makoto Anraku, Ryo Tabuchi, Shinsuke Ifuku, Tomone Nagae, Daisuke Iohara, Hisao Tomida, Kaneto Uekama, Toru Maruyama, Shigeyuki Miyamura, Fumitoshi Hirayama, Masaki Otagiri
  • Journal Title: Carbohydrate Polymers Volume: 161 Pages: 21-25
  • DOI: 10.1016/j.carbpol.2016.12.057
  • Peer Reviewed
• [Journal Article] Biomaterials based on freeze dried surface-deacetylated chitin nanofibers reinforced with sulfobutyl ether b-cyclodextrin gel in wound dressing application (2016)
  • Author(s): Ryo Tabuchi, Kazuo Azuma, Ryotaro Izumi, Tsubasa Tanou, Yoshiharu Okamoto, Tomone Nagae, Daisuke Iohara, Kaneto Uekama, Masaki Otagiri Fumitoshi Hirayama, Shinsuke Ifuku, Makoto Anraku
  • Journal Title: International Journal of Pharmaceutics Volume: 511 Issue: 2 Pages: 1080-1087
  • DOI: 10.1016/j.ijpharm.2016.08.019
  • Peer Reviewed
• [Journal Article] In Vitro and In Vivo Evaluation of Hydrophilic C60(OH)10/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as an Antioxidant. (2016)
  • Author(s): Iohara D, Umezaki Y, Anraku M, Uekama K, Hirayama F.
  • Journal Title: Journal of Pharmaceutical Sciences Volume: 105 Issue: 9 Pages: 2959-2965
  • DOI: 10.1016/j.xphs.2016.04.033
  • Peer Reviewed
• [Journal Article] Effect of a Ferric Citrate Formulation, a Phosphate Binder, on Oxidative Stress in Chronic Kidney Diseases-Mineral and Bone Disorder Patients Receiving Hemodialysis: A Pilot Study (2016)
  • Author(s): Tanaka M, Miyamura S, Imafuku T, Tominaga Y, Maeda H, Anraku M, Yamasaki K, Kadowaki D, Ishima Y, Watanabe H, Okuda T, Itoh K, Matsushita K, Fukagawa M, Otagiri M, Maruyama T
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 39 Issue: 6 Pages: 1000-1006
  • DOI: 10.1248/bpb.b15-01021
  • NAID: 130005155137
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparison of Posttranslational Modification and the Functional Impairment of Human Serum Albumin in Commercial Preparations (2016)
  • Author(s): Miyamura S, Imafuku T, Anraku M, Taguchi K, Yamasaki K, Tominaga Y, Maeda H, Ishima Y, Watanabe H, Otagiri M, Maruyama T
  • Journal Title: J Pharm Sci. Volume: 105 Issue: 3 Pages: 1043-1049
  • DOI: 10.1016/j.xphs.2015.12.015
  • Peer Reviewed
• [Journal Article] The formation of an inclusion complex between a metabolite of ginsenoside, compound K, and γ-cyclodextrin and its dissolution characteristics (2016)
  • Author(s): K. Igami, M. Ozawa, S. Inoue, D. Iohara, T. Miyazaki, M. Shinoda, M. Anraku, F. Hirayama and K. Uekama
  • Journal Title: J. Pharm. Pharmacol Volume: 印刷中 Issue: 5 Pages: 646-654
  • DOI: 10.1111/jphp.12468
  • Peer Reviewed / Open Access
• [Journal Article] Antioxidant and renoprotective activity of 2-hydroxypropyl-β-cyclodextrin in nephrectomized rats. (2016)
  • Author(s): Anraku M, Iohara D, Wada K, Taguchi K, Maruyama T, Otagiri M, Uekama K, Hirayama F.
  • Journal Title: Journal of Pharmacy and Pharmacology Volume: 68 Issue: 5 Pages: 608-614
  • DOI: 10.1111/jphp.12446
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ANTIOXIDANT EFFECTS OF THE HYDROXY GROUPS IN THE SIMPLE PHENOLIC CARBAZOLES (2016)
  • Author(s): Yuhzo Hieda, Noriyuki Hatae, Makoto Anraku, Nobuyasu Matsuura, Kazuhide Uemura, Satoshi Hibino, Tominari Choshi, Hisao Tomida, Osamu Hori, and Haruto Fujioka
  • Journal Title: HETEROCYCLES Volume: 92(1) Issue: 1 Pages: 120-132
  • DOI: 10.3987/com-15-13363
  • NAID: 120007007830
  • Peer Reviewed
• [Journal Article] N-acetyl-L-methionine is a superior protectant of human serum albumin against post-translational oxidation as compared to N-acetyl- L-tryptophan (2016)
  • Author(s): Kouno Y, Anraku M, Yamasaki K, Okayama Y, Iohara D, Nakamura H, Maruyama T, Hirayama F, Kragh-Hansen U, Otagiri M.
  • Journal Title: Biochemistry and BiophysicsReports Volume: 6 Pages: 266-274
  • DOI: 10.1016/j.bbrep.2016.04.011
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Surface-Deacetylated Chitin Nano-Fiber/Hyaluronic Acid Composites as Potential Antioxidative Compounds for Use in Extended-Release Matrix Tablets. (2015)
  • Author(s): Anraku M, Tabuchi R, Ifuku S, Ishiguro T, Iohara D, Hirayama F.
  • Journal Title: Int J Mol Sci. Volume: 16 Issue: 10 Pages: 24707-24717
  • DOI: 10.3390/ijms161024707
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Amino acids of importance for the antioxidant activity of human serum albumin as revealed by recombinant mutants and genetic variants. (2015)
  • Author(s): Anraku M, Shintomo R, Taguchi K, Kragh-Hansen U, Kai T, Maruyama T, Otagiri M.
  • Journal Title: Life Sci. Volume: 134 Pages: 36-41
  • DOI: 10.1016/j.lfs.2015.05.010
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Olmesartan protects endothelial cells against oxidative stress-mediated cellular injury. (2015)
  • Author(s): Kadowaki D, Anraku M, Sakaya M, Hirata S, Maruyama T, Otagiri M.
  • Journal Title: Clin Exp Nephrol. Volume: 19 Issue: 6 Pages: 1007-1014
  • DOI: 10.1007/s10157-015-1111-5
  • Peer Reviewed / Open Access
• [Journal Article] Slow-release of famotidine from tablets consisting of chitosan/sulfobutyl ether β-cyclodextrin composites. (2015)
  • Author(s): Anraku M, Hiraga A, Iohara D, Pipkin JD, Uekama K, Hirayama F.
  • Journal Title: Int J Pharm. Volume: 487 Issue: 1-2 Pages: 142-147
  • DOI: 10.1016/j.ijpharm.2015.04.022
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Preparation of Hydrophilic C60(OH)10/2-Hydroxypropyl-β-cyclodextrin Nanoparticles for the Treatment of a Liver Injury Induced by an Overdose of Acetaminophen (2015)
  • Author(s): Y. Umezaki, D. Iohara, M. Anraku, Y. Ishitsuka, T. Irie, K. Uekama and F. Hirayama
  • Journal Title: Biomaterials Volume: 45 Pages: 115-123
  • DOI: 10.1016/j.biomaterials.2014.12.032
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Application of the pleiotropic effects of chitosan to pharmaceutical fields (2015)
  • Author(s): Anraku M.
  • Journal Title: Chitin and chitosan research Volume: 21 Pages: 198-203
  • NAID: 40020641381
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Formation of elastic gels from deacetylated chitin nanofibers reinforced with sulfobutyl ehter beta-cyclodextrin (2015)
  • Author(s): Makoto Anraku, Daisuke Iohara, Ayumu Hiraga, Kaneto Uekama, Shinsuke Ifuku, James D. Pipkin, Fumitoshi Hirayama
  • Journal Title: Chemistry Letters Volume: 44 Issue: 3 Pages: 285-287
  • DOI: 10.1246/cl.141004
  • NAID: 130004703984
  • Peer Reviewed
• [Journal Article] Elucidation of the Mechanism Responsible for the Oxidation of Serum Albumin and Its Application in Treating Oxidative Stress-related Diseases (2014)
  • Author(s): Anraku M.
  • Journal Title: YAKUGAKU ZASSHI Volume: 134 Issue: 9 Pages: 973-979
  • DOI: 10.1248/yakushi.14-00166
  • NAID: 130004684826
  • ISSN: 0031-6903, 1347-5231
  • Year and Date: 2014-09-01
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cys34-cysteinylated human serum albumin is a sensitive plasma marker in oxidative stress-related chronic diseases (2014)
  • Author(s): K. Nagumo, M. Tanaka, VT. Chuang, H. Setoyama, H. Watanabe, N. Yamada, K. Kubota, M. Tanaka, K. Matsushita, A. Yoshida, H. Jinnouchi, M. Anraku, D. Kadowaki, Y. Ishima, Y. Sasaki, M. Otagiri, T. Maruyama.
  • Journal Title: PLoS One Volume: 9 Issue: 1 Pages: e85216-e85216
  • DOI: 10.1371/journal.pone.0085216
  • Peer Reviewed / Open Access
• [Journal Article] Potential Use of C60/2-Hydroxypropyl-β-cyclodextrin Nanoparticles as a New Photosensitizer in the Treatment of Cancer (2014)
  • Author(s): A. Altaf, H. Aldawsari, Z. M. Banjar, D. Iohara, M. Anraku, K. Uekama, F. Hirayama
  • Journal Title: International Journal of Photoenergy Volume: 2014 Pages: 1-8
  • DOI: 10.1155/2014/570506
  • Peer Reviewed
• [Journal Article] Differential effects of methoxy group on the interaction of curcuminoids with two major ligand binding sites of human serum albumin (2014)
  • Author(s): Sato H, Chuang VT, Yamasaki K, Yamaotsu N, Watanabe H, Nagumo K, Anraku M, Kadowaki D, Ishima Y, Hirono S, Otagiri M, Maruyama T
  • Journal Title: PLoS One Volume: 9 Issue: 2 Pages: e87919-e87919
  • DOI: 10.1371/journal.pone.0087919
  • Peer Reviewed
• [Journal Article] N-acetyl-Lmethionine is a superior protectant of human serum albumin against photooxidation and reactive oxygen species compared to N-acetyl-L-tryptophan (2014)
  • Author(s): Kouno Y, Anraku M, Yamasaki K, Okayama Y, Iohara D, Ishima Y, Maruyama T, Kragh-Hansen U, Hirayama F, Otagiri M
  • Journal Title: Biochim Biophys Acta Volume: (in press) Issue: 9 Pages: 2806-2812
  • DOI: 10.1016/j.bbagen.2014.04.014
  • Peer Reviewed
• [Journal Article] Antioxidant effects of the highly-substituted carbazole alkaloids and their related carbazoles. (2014)
  • Author(s): Hieda Y, Anraku M, Choshi T, Tomida H, Fujioka H, Hatae N, Hori O, Hirose J, Hibino S.
  • Journal Title: Bioorg Med Chem Lett. Volume: 24 Issue: 15 Pages: 3530-3
  • DOI: 10.1016/j.bmcl.2014.05.050
  • Peer Reviewed
• [Journal Article] Preparation and antioxidant activity of PEGylated chitosans with different particle sizes. (2014)
  • Author(s): Anraku M, Hiraga A, Iohara D, Uekama K, Tomida H, Otagiri M, Hirayama F.
  • Journal Title: Int J Biol Macromol. Volume: 70 Pages: 64-9
  • DOI: 10.1016/j.ijbiomac.2014.06.026
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effects of chitosan on oxidative stress and related factors in hemodialysis patients. (2014)
  • Author(s): Anraku M, Tanaka M, Hiraga A, Nagumo K, Imafuku T, Maezaki Y, Iohara D, Uekama K, Watanabe H, Hirayama F, Maruyama T, Otagiri M
  • Journal Title: Carbohydr Polym Volume: 112 Pages: 152-157
  • DOI: 10.1016/j.carbpol.2014.05.078
  • Peer Reviewed
• [Journal Article] Pleiotropic effects of chitosan on lifestyle-related diseases (2014)
  • Author(s): Anraku M, Maruyama T, Iohara D, Tomida H, Hirayama F, Otagiri M.
  • Journal Title: Kichin, Kitosan Kenkyu Volume: 20 Pages: 74-81
  • NAID: 40020148316
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] がん光線力学療法への応用を企図したC60-プロトポルフィリンIXハイブリットナノ粒子の調製 (2017)
  • Author(s): 庵原大輔、安楽 誠、上釜兼人、平山文俊
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際センター(宮城県、仙台市)
  • Year and Date: 2017-03-24
• [Presentation] キトサンナノファイバー/シクロデキストリンゲルシートの調製と物性評価 (2017)
  • Author(s): 田渕 良、安楽 誠、伊福伸介、庵原大輔、小田切 優樹、平山文俊
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際センター(宮城県、仙台市)
  • Year and Date: 2017-03-24
• [Presentation] キトサンナノファイバーゲルの滞留性を利用した潰瘍性大腸炎モデルマウスへの応用 (2017)
  • Author(s): 安楽 誠、田渕 良、庵原 大輔、伊福 伸介、小田切 優樹、平山 文俊
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 仙台国際センター(宮城県、仙台市)
  • Year and Date: 2017-03-24
• [Presentation] キトサンナノファイバー/シクロデキストリンゲルのDSS誘発潰瘍性大腸炎への応用 (2016)
  • Author(s): 田渕 良、安楽 誠、庵原 大輔、伊福 伸介、平山 文俊
  • Organizer: 第33回日本薬学会九州支部大会
  • Place of Presentation: 鹿児島大学(鹿児島県、鹿児島市)
  • Year and Date: 2016-12-03
• [Presentation] Sangelose/Cyclodextrin ゲルの温度応答性粘性変化の機構解明と点眼剤としての有用性評価 (2016)
  • Author(s): 大久保 尚徳、庵原 大輔、安楽 誠、上釜 兼人、平山 文俊
  • Organizer: 第33回日本薬学会九州支部大会
  • Place of Presentation: 鹿児島大学(鹿児島県、鹿児島市)
  • Year and Date: 2016-12-03
• [Presentation] グルクロニルグルコシル- -シクロデキストリン/ポリアクリル酸結合体の調製と可溶化能 (2016)
  • Author(s): 田渕良，高口恵理子，庵原大輔，安楽誠，平山文俊
  • Organizer: 第33回シクロデキストリンシンポジウム
  • Place of Presentation: かがわ国際会議場 (香川県、高松市)
  • Year and Date: 2016-09-08
• [Presentation] 温度応答性 Sangelose/Cyclodextrin ゲルを用いた薬物の結膜嚢滞留性の改善 (2016)
  • Author(s): 大久保尚徳, 庵原大輔, 安楽誠, 上釜兼人, 平山文俊
  • Organizer: 第33回シクロデキストリンシンポジウム
  • Place of Presentation: かがわ国際会議場 (香川県、高松市)
  • Year and Date: 2016-09-08
• [Presentation] シクロデキストリン/キトサンナノファイバーコンポジットゲルの放出制御製剤への応用 (2016)
  • Author(s): 田渕 良、安楽 誠、伊福伸介、庵原大輔、平山文俊
  • Organizer: 第30回日本キチン・キトサン学会大会
  • Place of Presentation: ウエスタ川越 (埼玉県、川越市)
  • Year and Date: 2016-08-18
• [Presentation] シクロデキストリン/キトサンナノファイバーコンポジットゲルの創傷治癒への応用 (2016)
  • Author(s): 安楽誠、田渕良、東和生、伊福伸介、庵原大輔、平山文俊
  • Organizer: 第30回日本キチン・キトサン学会大会
  • Place of Presentation: ウエスタ川越 (埼玉県、川越市
  • Year and Date: 2016-08-18
• [Presentation] Pleiotropic effects of chitosan and chitosan-nanofibers on oxidative stress related diseases (2016)
  • Author(s): Makoto Anraku
  • Organizer: International Conferense on Small Science
  • Place of Presentation: Prague (Czech Republic)
  • Year and Date: 2016-06-25
  • Int'l Joint Research / Invited
• [Presentation] シクロデキストリン/キトサンナノファイバーコンポジットゲルの徐放性素材への応用 (2016)
  • Author(s): 田渕 良、安楽 誠、庵原大輔、伊福伸介、平山文俊
  • Organizer: 日本薬剤学会第31年会
  • Place of Presentation: 長良川国際会議場 (岐阜県、岐阜市)
  • Year and Date: 2016-05-19
• [Presentation] 慢性腎不全モデルラットにおけるキトサンナノファイバーの抗酸化及び腎保護効果 (2016)
  • Author(s): 安楽 誠、田渕 良、庵原大輔、伊福伸介、小田切優樹、平山文俊
  • Organizer: 日本薬剤学会第31年会
  • Place of Presentation: 長良川国際会議場 (岐阜県、岐阜市)
  • Year and Date: 2016-05-19
• [Presentation] Preparation of Hydrophilic C60(OH)10/2-Hydroxypropyl-β-cyclodextrin Nanoparticles for the Treatment of Liver Injury Induced by Oxidative Stress (2016)
  • Author(s): Daisuke Iohara, Yoshitaka Umezaki, Makoto Anraku, Kaneto Uekama and Fumitoshi Hirayama
  • Organizer: 10th Biomaterials Congress
  • Place of Presentation: Montreal (Canada)
  • Year and Date: 2016-05-17
  • Int'l Joint Research
• [Presentation] シクロデキストリン／キトサンナノファイバーゲルの創傷治癒促進効果 (2016)
  • Author(s): 安楽誠、田渕良、東 和生、伊福伸介、庵原大輔、上釜兼人、小田切優樹、平山文俊
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県、横浜市）
  • Year and Date: 2016-03-26
• [Presentation] シクロデキストリン-キトサンナノファイバーゲルの徐放性素材への応用 (2015)
  • Author(s): 田渕 良、安楽 誠、庵原大輔、伊福伸介、小田切優樹、平山文俊
  • Organizer: 第32回日本薬学会九州支部学会大会
  • Place of Presentation: 九州保健福祉大学（宮崎県、延岡市）
  • Year and Date: 2015-11-28
• [Presentation] Preparation of Hydrophilic C60(OH)10/2-Hydroxypropyl-β-cyclodextrin Nanoparticles for the Treatment of a Liver Injury Induced by an Overdose of Acetaminophen (2015)
  • Author(s): Yoshitaka Umezaki, Daisuke Iohara, Makoto Anraku, Yoichi Ishitsuka, Tetsumi Irie, Kaneto Uekama and Fumitoshi Hirayama
  • Organizer: Asian Federation for Pharmaceutical Sciences Conference 2015
  • Place of Presentation: Bangkok, Thailand
  • Year and Date: 2015-11-25
  • Int'l Joint Research
• [Presentation] Effects of chitosan on oxidative stress and related factors in chronic renal failure (2015)
  • Author(s): Makoto Anraku, Daisuke Iohara, Motoko Tanaka, Toru Maruyama, Fumitoshi Hirayama, Masaki Otagiri
  • Organizer: 12th International Conference of the European Chitin Society 13th International Conference on Chitin and Chitosan
  • Place of Presentation: Munster, Germany
  • Year and Date: 2015-08-30
  • Int'l Joint Research
• [Presentation] Cyclodextrin/Chitosan 複合体による薬物徐放性システムの構築 (2015)
  • Author(s): 安楽 誠、前崎祐二、庵原大輔、平山文俊
  • Organizer: 第29回日本キチンキトサン学会大会
  • Place of Presentation: 東海大学熊本キャンパス（熊本県、熊本市）
  • Year and Date: 2015-08-20
• [Presentation] キトサンの多面的作用に基づく生活習慣病への予防・治療戦略 (2015)
  • Author(s): 安楽 誠
  • Organizer: 第29回日本キチンキトサン学会大会
  • Place of Presentation: 東海大学熊本キャンパス（熊本県、熊本市）
  • Year and Date: 2015-08-20
• [Presentation] 水酸化フラーレン/シクロデキストリンナノ粒子の調製とアセトアミノフェン誘発肝障害抑制効果 (2015)
  • Author(s): 庵原大輔、梅崎至高、安楽誠、石塚洋一、入江徹美、上釜兼人、平山文俊
  • Organizer: 第64会高分子学会年次大会
  • Place of Presentation: 札幌コンベンションセンター (北海道、札幌市)
  • Year and Date: 2015-05-27
• [Presentation] シクロデキストリン-キトサンナノファイバーゲルの徐放性素材への応用 (2015)
  • Author(s): 平賀 歩，安楽 誠，庵原大輔，伊福伸介 ，小田切優樹, 上釜兼人,平山文俊
  • Organizer: 日本薬剤学会第30年会
  • Place of Presentation: 長崎ブリックホール（長崎県、長崎市）
  • Year and Date: 2015-05-21
• [Presentation] イソソルビドとβ-シクロデキストリンとの複合体形成 (2015)
  • Author(s): 田渕 良、川瀬大輝、庵原大輔、安楽誠、山口幸輝、衛藤 仁、平山文俊
  • Organizer: 日本薬剤学会第30年会
  • Place of Presentation: 長崎ブリックホール（長崎県、長崎市）
  • Year and Date: 2015-05-21
• [Presentation] Antioxidant and renoprotective activity of 2-hydroxypropyl-β-cyclodextrin in nephrectomized rats (2015)
  • Author(s): Makoto Anraku, Daisuke Iohara, Koki Wada, Kaneto Uekama, Fumitoshi Hirayama
  • Organizer: Joint Conference of 8th Asian Cylodextrin Conference and 32nd Cyclodextrin Symposium
  • Place of Presentation: くまもと県民交流館パレア（熊本県、熊本市）
  • Year and Date: 2015-05-14
  • Int'l Joint Research
• [Presentation] Formation of Elastic Gels from Deacetylated Chitin Nanofibers Reinforced with Sulfobutyl Ether β-Cyclodextrin (2015)
  • Author(s): Makoto Anraku, Daisuke Iohara, Ayumu Hiraga, Kaneto Uekama, Shinsuke Ifuku, J.D. Pipkin and Fumitoshi Hirayama
  • Organizer: 7th Iberoamerican Chitin Symposium
  • Place of Presentation: Nuevo Vallarta （Mexico）
  • Year and Date: 2015-04-20
  • Int'l Joint Research
• [Presentation] スルホブチル-β-シクロデキストリンによるキトサンナノファイバーゲルの調製 (2015)
  • Author(s): 安楽誠，平賀歩，庵原大輔，伊福伸介，小田切優樹, 平山文俊
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸学院大学（兵庫県、神戸市）
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] シクロデキストリンを利用した親水性フラーレンナノ粒子の調製と抗腫瘍・抗酸化効果の評価 (2014)
  • Author(s): 庵原大輔，梅崎至高，安楽誠，上釜兼人，平山文俊
  • Organizer: 第36回日本バイオマテリアル学会大会
  • Place of Presentation: タワーホール船堀（東京都、豊島区）
  • Year and Date: 2014-11-17 – 2014-11-18
• [Presentation] Antioxidant and renoprotective activity of 2-hydroxypropyl-beta-cyclodextrin in nephrectomized rats (2014)
  • Author(s): Anraku M, Iohara D, Uekama K,Otagiri M, Hirayama F.
  • Organizer: 19th North American ISSX Meeting / 29th JSSX Meeting
  • Place of Presentation: サンフランシスコ（USA）
  • Year and Date: 2014-10-19 – 2014-10-24
• [Presentation] 健康食品の腎不全治療への応用：透析患者におけるキトサンの抗酸化作用の定量的解析 (2014)
  • Author(s): 安楽 誠, 田中元子，南雲恒平，渡邊博志，庵原大輔，平山文俊，丸山 徹，小田切優樹
  • Organizer: 第24回日本医療薬学会年会
  • Place of Presentation: 名古屋国際会議場（愛知県、名古屋市）
  • Year and Date: 2014-09-27 – 2014-09-28
• [Presentation] Cyclodextrin/chitosan 複合体による薬物徐放性システムの構築 (2014)
  • Author(s): 髙良裕、庵原大輔、安楽誠、上釜兼人、平山文俊
  • Organizer: 第31回シクロデキストリンシンポジウム
  • Place of Presentation: 島根県民会館（島根県、松江市）
  • Year and Date: 2014-09-11 – 2014-09-12
• [Presentation] 慢性腎不全モデルラットにおける各種シクロデキストリンの抗酸化及び腎保護効果の検討 (2014)
  • Author(s): 安楽 誠、藤原里奈、和田幸樹、梅崎至高、庵原大輔、上釜兼人、平山文俊
  • Organizer: 第31回シクロデキストリンシンポジウム
  • Place of Presentation: 島根県民会館（島根県、松江市）
  • Year and Date: 2014-09-11 – 2014-09-12
• [Presentation] キトサン－シクロデキストリン複合体を利用した徐放性素材への応用 (2014)
  • Author(s): 安楽 誠, 平賀歩, 髙良裕, 前崎祐二, 小田切優樹, 庵原大輔, 平山文俊
  • Organizer: 第28回キチン・キトサンシンポジウム
  • Place of Presentation: 順天堂大学（東京都、文京区）
  • Year and Date: 2014-08-07 – 2014-08-08
• [Presentation] キチンナノファイバーを利用した徐放性素材への応用 (2014)
  • Author(s): 平賀 歩，安楽 誠，庵原大輔，伊福伸介，小田切優樹, 平山文俊
  • Organizer: 第28回キチン・キトサンシンポジウム
  • Place of Presentation: 順天堂大学（東京都、文京区）
  • Year and Date: 2014-08-07 – 2014-08-08
• [Presentation] アセトアミノフェン誘発肝障害に対する親水性C60（OH）10/HP-β-CyDナノ粒子の抗酸化効果 (2014)
  • Author(s): 梅﨑至高、庵原大輔、安楽 誠, 石塚洋一, 入江徹美, 上釜兼人, 平山文俊
  • Organizer: 日本薬剤学会第29年会
  • Place of Presentation: 大宮ソニックシティビル（埼玉県、さいたま市）
  • Year and Date: 2014-05-20 – 2014-05-22
• [Presentation] 慢性腎不全モデルラットにおける2-ヒドロキシプロピル-β-シクロデキストリンの腎保護及び酸化ストレス抑制効果 (2014)
  • Author(s): 平賀 歩, 安楽 誠, 和田幸樹, 庵原大輔, 小田切 優樹, 上釜兼人, 平山文俊
  • Organizer: 日本薬剤学会第29年会
  • Place of Presentation: 大宮ソニックシティビル（埼玉県、さいたま市）
  • Year and Date: 2014-05-20 – 2014-05-22
• [Book] 6．キチン・キトサンの最新科学技術「キトサンの抗酸化作用を利用した酸化ストレス関連疾患への応用」 (2016)
  • Author(s): 一般社団法人 日本キチンキトサン学会 編
  • Total Pages: 276
  • Publisher: 技報堂出版
• [Book] Human Serum Albumin (HSA): Functional Structure, Synthesis and Therapeutic Uses (2015)
  • Author(s): Makoto Anraku, Ulrich Kragh-Hansen, Toru Maruyama and Masaki Otagiri
  • Publisher: Nova Science Publishers
• [Remarks] 崇城大学製剤学研究室
  • URL: http://www.ph.sojo-u.ac.jp/~dio/index.html
• [Remarks] 崇城大学 薬学部 製剤学研究室ホームページ
• [Remarks] 崇城大学薬学部製剤学研究室
  • URL: http://www.ph.sojo-u.ac.jp/~dio/
• [Patent(Industrial Property Rights)] Renal failure-ameliorating agent containing β-cyclodextrin or its derivative (2015)
  • Inventor(s): Anraku M, Hirayama F, Wada K.
  • Industrial Property Rights Holder: 日本食品化工（株）
  • Industrial Property Rights Type: 特許
  • Filing Date: 2015-01-19