Research Project
Grant-in-Aid for Scientific Research (C)
Purkinje cells receive two excitatory inputs, parallel fiber (PF) and climbing fiber (CF). This PC circuitry is established by heterosynaptic competition between PF and CF, fueled by glutamate receptor GluRδ2 and voltage-gated calcium ion channel Cav2.1, respectively. However, it has been unclear whether this heterosynaptic competition maintains PC circuitry in the adult cerebellum. To uncover this question, I investigated novel mouse line, in which Cav2.1 gene can be deleted in adult PCs by the drug-induced ablation system. In anatomical and electrophysiological investigation, inducible Cav2.1 ablation in the adult cerebellum caused motor discoordination and imbalance of heterosynaptic competiton with proximal expansion of PF territory. Therefore, Cav2.1 fuels CF inputs and balance heterosynaptic competition in the adult cerebellum. This result strongly suggests that the balance of heterosynaptic competition is essential for the cerebellar function.
All 2017 2016 2015 2014
All Journal Article (12 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 12 results, Open Access: 9 results, Acknowledgement Compliant: 8 results) Presentation (8 results) (of which Int'l Joint Research: 1 results) Book (1 results)
Cell Reports
Volume: 16 Issue: 4 Pages: 994
10.1016/j.celrep.2016.06.053
https://pure.teikyo.jp/en/publications/3ce87e4a-7df7-4d28-8c16-070ceff28970
Eur J Neurosci.
Volume: 44 Issue: 5 Pages: 2272-2284
10.1111/ejn.13331
Proc. Natl. Acad. Sci. USA,
Volume: 113 Issue: 23 Pages: 6550-6555
10.1073/pnas.1605019113
Proc Natl Acad Sci U S A
Volume: 113 Issue: 8 Pages: 2282
10.1073/pnas.1511513113
120005828473
https://pure.teikyo.jp/en/publications/ef6116f6-3235-46cc-b619-656ef2bb4818
J Neurosci.
Volume: 35(10) Issue: 10 Pages: 4215-4228
10.1523/jneurosci.4681-14.2015
Volume: 35 Issue: 2 Pages: 843
10.1523/jneurosci.2170-14.2015
https://pure.teikyo.jp/en/publications/1cc3b0d1-49e6-4b07-a3f2-52dca89fc01e
Nat Med
Volume: 21 Issue: 1 Pages: 19-26
10.1038/nm.3759
Nat. Commun.
Volume: 5 Issue: 1 Pages: 5586-5586
10.1038/ncomms6586
https://pure.teikyo.jp/en/publications/0b75dfc4-6db1-4d67-834f-289c5e61bd65
PLoS ONE
Volume: 9 (9) Issue: 9 Pages: 1-12
10.1371/journal.pone.0107867
Cell Rep.
Volume: 8 Issue: 4 Pages: 1119
10.1016/j.celrep.2014.07.014
https://pure.teikyo.jp/en/publications/2079c7db-ebb4-499b-af8c-505bb234affb
Eur J Neurosci,
Volume: 40 Issue: 5 Pages: 2797-2810
10.1111/ejn.12636
Volume: 34(22) Issue: 22 Pages: 7412-24
10.1523/jneurosci.0628-14.2014
120005537463