Investigation of the mechanisms involved in both obtainment of ocular preference of premature neurons and grouping of same ocular preference neurons during cortical development.

• Project/Area Number: 26460298
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General physiology
• Research Institution: Kochi University
• Principal Investigator: TOMITA Koichi 高知大学, 教育研究部医療学系基礎医学部門, 准教授 (80314285)
• Co-Investigator(Kenkyū-buntansha): 由利 和也 高知大学, 教育研究部医療学系基礎医学部門, 教授 (10220534)
• Research Collaborator: HIRABAYASHI Masumi ; SANBO Makoto
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 眼優位カラム / 初期形成プロセス / 可塑的発達プロセス / 形成メカニズム / 機能ユニット / 初期形成メカニズム / 可塑的発達メカニズム / シャペロン

Outline of Final Research Achievements

Ocular dominance (OD) columns are known to be fundamental units of processing visual information to sense depth in the primary visual cortex. Coarse OD columns are set up by molecular cues before eye open, which are subsequently remodeled to the functional structure by visual activity after eye open. In the initial step, premature neurons endowed with same ocular preference are grouped into columnar architectures. Our recent data implied that both obtainment of ocular preference of premature neurons and grouping of same preference neurons were regulated by common mechanisms. We are now analyzing the function of a candidate molecule that might be involved in the control of the initial step.

Research Products

• [Journal Article] Macrophage infiltration into obese adipose tissues suppresses the induction of UCP1 expression in mice. (2016)
  • Author(s): Sakamoto T, Nitta T, Maruno K, Yeh YS, Kuwata H, Tomita K, Goto T, Takahashi N, Kawada T.
  • Journal Title: Am. J. Physiol. Endocrinol. Metab. Volume: - Issue: 8 Pages: E676-E687
  • DOI: 10.1152/ajpendo.00028.2015
  • Peer Reviewed
• [Journal Article] Identification of hypothalamic arcuate nucleus-specific enhancer region of kiss1 gene in mice. (2015)
  • Author(s): Goto, T., Tomikawa, J., Ikegami, K., Minabe, S., Abe, H., Fukanuma, T., Imamura, T., Takase, K., Sanbo, M., Tomita, K., Hirabayashi, M., Maeda, K., Tsukamura, H., Uenoyama, Y.
  • Journal Title: Mol Endocrinol Volume: 29 Issue: 1 Pages: 121-129
  • DOI: 10.1210/me.2014-1289
  • Peer Reviewed / Open Access
• [Journal Article] Bre1a, a histone H2B ubiquitin ligase, regulates the cell cycle and differentiation of neural precursor cells. (2014)
  • Author(s): Ishino Y, Hayashi Y, Naruse M, Tomita K, Sanbo M, Fuchigami T, Fujiki R, Hirose K, Toyooka Y, Fujimori T, Ikenaka K, Hitoshi S.
  • Journal Title: The Journal of Neuroscience Volume: 34 Issue: 8 Pages: 3067-78
  • DOI: 10.1523/jneurosci.3832-13.2014
  • Peer Reviewed / Open Access
• [Presentation] 発達期の高等哺乳類第一次視覚野において層特異的に発現している遺伝子の同定. (2014)
  • Author(s): 冨田 江一, 山内奈央子, 三宝誠, 由利 和也.
  • Organizer: 第37回日本神経科学大会/Neuroscience2014
  • Place of Presentation: パシフィコ横浜 (横浜)
  • Year and Date: 2014-09-11
• [Book] 水素核融合に向けての基礎的諸問題 (2016)
  • Author(s): 冨田 達也, 冨田 江一
  • Total Pages: 85
  • Publisher: 三重大学出版会
• [Remarks] 高知大学医学部 - 解剖学
  • URL: http://www.kochi-ms.ac.jp/html/gakubu/ff_antm1.html