The molecular mechanism of resilience: an association between prolactin releasing peptide and neurogenesis

• Project/Area Number: 26460321
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Jichi Medical University
• Principal Investigator: Yoshida Masahide 自治医科大学, 医学部, 助教 (30533955)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ストレス / プロラクチン放出ペプチド / レジリエンス / 心的外傷後ストレス障害 / 社会的敗北ストレス

Outline of Final Research Achievements

Social defeat stress activated prolactin releasing peptide (PrRP)-synthesizing neurons in the dorsomedial hypothalamic nucleus, caudal nucleus tractus solitarii and ventrolateral medulla. PrRP deficient mice were suggested to have a lower fear threshold. PrRP may prevent the development of post-traumatic stress disorder (PTSD).

Research Products

• [Journal Article] Activation of supraoptic oxytocin neurons by secretin facilitates social recognition. (2015)
  • Author(s): Takayanagi Y, Yoshida M, Takashima A, Takanami K, Yoshida S, Nishimori K, Nishijima I, Sakamoto H, Yamagata T, Onaka T
  • Journal Title: Biological Psychiatry Volume: in press Issue: 3 Pages: 243-251
  • DOI: 10.1016/j.biopsych.2015.11.021
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Activation of hypothalamic oxytocin neurons following tactile stimuli in rats. (2015)
  • Author(s): Okabe S, Yoshida M, Takayanagi Y, Onaka T
  • Journal Title: Neuroscience Letters Volume: 600 Pages: 22-27
  • DOI: 10.1016/j.neulet.2015.05.055
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors. (2015)
  • Author(s): Onaka T, Okabe S, Takayanagi Y, Yoshida M
  • Journal Title: Interdisciplinary Information Sciences Volume: 21 Issue: 3 Pages: 189-195
  • DOI: 10.4036/iis.2015.b.03
  • NAID: 110009966527
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Oxytocin Receptor-Expressing Neurons and Nuclei in the Regulation of Social Behaviors (2015)
  • Author(s): Nishimori K, Sato K, Hidema S, Yoshida M, Mizukami H
  • Journal Title: Interdisciplinary Information Sciences Volume: 21 Issue: 3 Pages: 283-288
  • DOI: 10.4036/iis.2015.B.14
  • NAID: 110009966538
  • ISSN: 1340-9050, 1347-6157
  • Peer Reviewed
• [Journal Article] 不安・恐怖とオキシトシン (2015)
  • Author(s): 尾仲達史、吉田匡秀、高柳友紀
  • Journal Title: アンチエイジング医学 Volume: 11 Pages: 24-33
• [Presentation] Transgene expression and site-specific ablation in oxytocin system by making use of transgenic animals and virus vectors. (2017)
  • Author(s): Masahide Yoshida, Yuki Takayanagi, Ayumu Inutsuka, Tatsushi Onaka
  • Organizer: The 94th Annual Meeting of the Physiological Society of Japan
  • Place of Presentation: アクトシティー浜松(静岡県浜松市)
  • Year and Date: 2017-03-28
  • Invited
• [Presentation] 社会行動におけるオキシトシンの働き (2017)
  • Author(s): 高柳友紀、吉田匡秀、尾仲達史
  • Organizer: 第122回日本解剖学会総会・全国学術集会
  • Place of Presentation: 長崎大学坂本キャンパス(長崎県長崎市)
  • Year and Date: 2017-03-28
  • Invited
• [Presentation] 視床下部特定回路の活動操作と活動記録 (2016)
  • Author(s): 犬束歩、吉田匡秀、高柳友紀、山中章弘、尾仲達史
  • Organizer: 第44回 自律神経生理研究会
  • Place of Presentation: 日本光電工業(株)フェニックスアカデミー(東京都新宿区)
  • Year and Date: 2016-12-03
• [Presentation] Do stroking stimuli induce a pleasant sensation in rats? (2016)
  • Author(s): Okabe S, Takayanagi Y, Yoshida M, Inutsuka A, Onaka T
  • Organizer: Annual Meeting of the Japanese Society for Animal Psychology
  • Place of Presentation: 北海道大学 学術交流会館(北海道札幌市)
  • Year and Date: 2016-11-23
• [Presentation] 接触刺激に対するラット視床下部オキシトシン産生細胞の活性化と超音波発声. (2015)
  • Author(s): 岡部祥太、吉田匡秀、高柳友紀、尾仲達史
  • Organizer: 第42回日本神経内分泌学会 第23回日本神経行動内分泌研究会 合同学術集会
  • Place of Presentation: 仙台市戦災復興記念館
  • Year and Date: 2015-09-18
• [Presentation] Noxious or Non-Noxious Inputs to Oxytocin Neurons: Possible Roles in the Control of Behaviors. (2015)
  • Author(s): Onaka T, Takayanagi Y, Yoshida M, Okabe S
  • Organizer: Parvo- and Magnocellular Symposium in Sendai
  • Place of Presentation: Sendai, Japan
  • Year and Date: 2015-09-17
  • Int'l Joint Research / Invited
• [Presentation] レジリエンスの分子機構. (2015)
  • Author(s): 吉田 匡秀
  • Organizer: 平成２７年度栃木県小児保健会総会・研修会
  • Place of Presentation: 自治医科大学
  • Year and Date: 2015-06-06
  • Invited
• [Presentation] Roles of oxytocin in the control of emotional and social behaviors. (2015)
  • Author(s): Takayanagi Y, Yoshida M, Onaka T
  • Organizer: The 92nd Annual Meeting of the Physiology Society of Japan
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] Roles of the medial amygdala in the control of neuroendocrine responses to conditioned fear stimuli. (2015)
  • Author(s): Onaka T, Yoshida M, Takayanagi Y
  • Organizer: The 92nd Annual Meeting of the Physiology Society of Japan
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] 神経ペプチド産生細胞を特異的に破壊するためのトランスジェニックラットの作製 (2015)
  • Author(s): 吉田匡秀、高柳友紀、尾仲達史
  • Organizer: 第２回共感性の進化・神経基盤領域班会議
  • Place of Presentation: 奈良、日本
  • Year and Date: 2015-01-09 – 2015-01-10
• [Presentation] Emotional contagion of social defeat: activation of oxytocin/oxytocin receptor system (2015)
  • Author(s): Naranbat Nasanbuyan, Masahide Yoshida, Yuki Takayanagi, Tatsushi Onaka
  • Organizer: 第２回共感性の進化・神経基盤領域班会議
  • Place of Presentation: 奈良、日本
  • Year and Date: 2015-01-09 – 2015-01-10
• [Presentation] Lesions of vasopressin neurons by use of vasopressin-DTR transgenic rats. (2014)
  • Author(s): Onaka T, Yoshida M, Takayanagi Y
  • Organizer: Satellite meeting of ICN 2014
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2014-08-16
• [Remarks] 自治医科大学医学部生理学講座神経脳生理学部門HP
  • URL: http://www.jichi.ac.jp/usr/pys1/admnpys1/