The molecular mechanism of resilience: an association between prolactin releasing peptide and neurogenesis
| Project/Area Number |
26460321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ストレス / プロラクチン放出ペプチド / レジリエンス / 心的外傷後ストレス障害 / 社会的敗北ストレス |
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| Outline of Final Research Achievements |
Social defeat stress activated prolactin releasing peptide (PrRP)-synthesizing neurons in the dorsomedial hypothalamic nucleus, caudal nucleus tractus solitarii and ventrolateral medulla. PrRP deficient mice were suggested to have a lower fear threshold. PrRP may prevent the development of post-traumatic stress disorder (PTSD).
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Report
(4 results)
Research Products
(18 results)
