| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Recent studies have revealed that hematopoietic stem cells (HSCs) form heterogeneous population with extremely diverse biological properties. By maintaining the heterogeneity, HSCs maintain the hematopoietic system for whole life, and it seems that it contributes to respond to various stresses. In this study, we focused on mTOR complex and forkhead transcription factor, FOXO, which are essential for survival and cell cycle regulation, and we identified molecules that are regulated by these pathways. Furthermore, by performing CRISPR/Cas9 screening system, we identified multiple functional molecules that contribute to regulate heterogeneity of HSCs and leukemic stem cells.
|
