Global dynamics of malaria parasites using an advanced technology of population genomics
Project/Area Number |
26460515
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Parasitology (including sanitary zoology)
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Research Institution | Juntendo University |
Principal Investigator |
Mita Toshihiro 順天堂大学, 医学(系)研究科(研究院), 教授 (80318013)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | マラリア / アルテミシニン / 耐性 / 進化 / K13 / マイクロサテライト / 薬剤耐性 / 地理的拡散 / 集団遺伝 / 集団遺伝学 |
Outline of Final Research Achievements |
This study aimed to clarify an global emergence and spread of artemisinin-resistant Plasmodium falciparum parasites. We identified several artemisinin-resistant parasites in Uganda. Before our discovery, it was believed that artemisinin-resistance has not been emerged in Africa and thus, this is the first identification of artemisinin resistance in Africa. We also found that an origin of resistant parasites was not in Southeast Asia where resistant parasites have emerged and spread into the area. Rather, artemsinin resistance indigenously appeared in some part in Africa.
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Academic Significance and Societal Importance of the Research Achievements |
マラリアは世界三大感染症のひとつである。第一選択薬であるアルテミシニンに対する耐性原虫はすでに東南アジアの一部地域では蔓延化しているが、今回の研究で世界で初めてアフリカにも出現していることを見出した。さらに、その起源は東南アジアからの移入ではなく、アフリカにあることを解明した。本成果は、薬剤耐性マラリア原虫がアフリカからも出現することを明らかにし、当地における薬剤耐性マラリアサーベイランスの重要性を示すものである。
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Report
(5 results)
Research Products
(42 results)
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[Journal Article] Artemisinin-Resistant Plasmodium falciparum with High Survival Rates, Uganda, 2014-20162018
Author(s)
Ikeda M, Kaneko M, Tachibana S-I, Balikagala B, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Yamauchi M, Sekihara M, Hashimoto M, Katuro OT, Olia A, Obwoya PS, Auma MA, Anywar DA, Odongo-Aginya EI, Okello-Onen J, Hirai M, Ohashi J, Palacpac NMQ, Kataoka M, Tsuboi T, Kimura E, Horii T, Mita T.
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Journal Title
Emerging Infectious Diseases
Volume: 24
Issue: 4
Pages: 718-726
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Absence of in-vivo selection for K13 mutations after artemether-lumefantrine treatment in Uganda.2017
Author(s)
Balikagala B, Mita T*, Ikeda M, Sakurai M, Yatsushiro S, Takahashi N, Tachibana SI, Auma M, Ntege EH, Ito D, Takashima E, Palacpac NM, Egwang TG, Ohashi J, Kataoka M, Kimura E, Horii T and Tsuboi T.
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Journal Title
Absence of in-vivo selection for K13 mutations after artemether-lumefantrine treatment in Uganda.
Volume: 16
Pages: 23-23
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Little polymorphism at the K13 propeller locus in worldwide Plasmodium falciparum populations prior to the introduction of artemisinin combination therapies.2016
Author(s)
Mita T*, Culleton R, Takahashi N, Nakamura M, Tsukahara T, Hunja CW, Win ZZ, Htike WW, Marma AS, Dysoley L, Ndounga M, Dzodzomenyo M, Akhwale WS, Kobayashi J, Uemura H, Kaneko A, Hombhanje F, Ferreira MU, Bjorkman A, Endo H, Ohashi J.
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Journal Title
Antimicrobial agents and chemotherapy
Volume: 60
Pages: 3340-3347
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Detection of artemisinin-resistant Plasmodium falciparum isolates with ex-vivo ring-stage survival assay in Uganda.2017
Author(s)
Mita T, Ikeda M, Kaneko M, Balikagala B, Tachibana S-I, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Hashimoto M, Katuro O, Olia A, Obwoya P, Auma M, Anywar D, Odongo-Aginya E, Hirai M, Palacpac N, Kataoka M, Tsuboi T, Kimura E,Horii T.
Organizer
Keystone Symposia Conference: Malaria: From Innovation to Eradication.
Place of Presentation
Speke Resort & Conference Centre, Kampala.
Year and Date
2017-02-19
Related Report
Int'l Joint Research
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[Presentation] ウガンダにおけるin vivo薬剤耐性試験およびRSAを用いたアルテミシニン耐性疫学調査2017
Author(s)
池田美恵, 橘真一郎, 山内祐人, Auma M, 関原誠, 森稔幸, 平井誠, Palacpac N, 木村英作, Aginya E, 堀井俊宏, 美田敏宏
Organizer
第86回日本寄生虫学会大会
Related Report
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[Presentation] ウガンダにおける熱帯熱マラリア原虫キニーネ感受性の実態2017
Author(s)
山内祐人, 橘真一郎, 池田美恵, 関原誠, Balikagala B, 八代?櫻井美樹, 平井誠, Palacpac N, 木村英作, 堀井俊宏, 美田敏宏
Organizer
第86回日本寄生虫学会大会
Related Report
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[Presentation] 宿主内競争による熱帯熱マラリア原虫のクロロキン感受性の回復2017
Author(s)
橘真一郎, 池田美恵, Balikagala B, 櫻井美樹, 八代聖基, 関原誠, 山内祐人, Auma MA, 平井誠, 森稔幸, Palacpac N, 片岡正俊, 木村英作, 堀井俊宏, 美田敏宏
Organizer
第86回日本寄生虫学会大会
Related Report
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[Presentation] Detection of artemisinin-resistant Plasmodium falciparum isolates with ex-vivo ring-stage survival assay in Uganda2017
Author(s)
Mita T, Ikeda M, Kaneko M, Balikagala B, Tachibana S-I, Sakurai-Yatsushiro M, Yatsushiro S, Takahashi N, Hashimoto M, Katuro O, Olia A, Obwoya P, Auma M, Anywar D, Odongo-Aginya E, Hirai M, Palacpac N, Kataoka M, Tsuboi T, Kimura E, Horii T
Organizer
Keystone Symposia Conference: Malaria: From Innovation to Eradication
Related Report
Int'l Joint Research
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[Presentation] Application of a cell microarray chip system for accurate, highly sensitive, and rapid diagnosis for malaria2017
Author(s)
Kataoka M, Yatsushiro S, Yamamoto T, Oka H, Okello-Onen J, Odongo-Aginya E, Palacpac N, Mita T, Baba Y, Horii T
Organizer
Keystone Symposia Conference: Malaria: From Innovation to Eradication
Related Report
Int'l Joint Research
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