| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We have constructed peptide libraries for matrix (MA) and capsid (CA) proteins of HIV-1 and investigated whether introduction of these peptides could inhibit HIV-1 replication in cell culture. We found that 9th fragment of the MA proteins, several fragments of the CA proteins including 15th fragment which contains the linker region of N- and C-terminal domains of CA and 19th fragment which contains the dimmer interface of C-terminal domain of CA have modest anti-HIV-1 activities in vitro, suggesting that these peptides could be lead compounds for further modifications.
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