| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Outline of Final Research Achievements |
Positive selection is recognized as a process to determine the T cell repertoire, since it selects potentially useful immature T cells based on the affinity between antigen receptors expressed on thymocytes and self-peptide-MHC complexes on cortical thymic epithelial cells. However, the recent finding of the thymoproteasome, which produces self-peptides in cortical thymic epithelial cells and plays a central role in positive selection, provided us an opportunity to revisit the physiological role of positive selection. In the present study, we analyzed the function of monoclonal T cells that have developed in the thymus of thymoproteasome-deficient mice and found that positive selection affects not only T cell repertoire but also antigen responsiveness and memory formation. Our finding unveiled a novel role of positive selection in T cell development.
|
