Expression of Ly6C/6G defines a novel Aire-dependent subset of medullary thymic epithelial cells with tolerogenic function
Project/Area Number |
26460577
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Immunology
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Research Institution | The University of Tokushima |
Principal Investigator |
MORIMOTO Junko 徳島大学, 先端酵素学研究所(次世代), 助教 (20451396)
|
Co-Investigator(Kenkyū-buntansha) |
松本 満 徳島大学, 先端酵素学研究所(次世代), 教授 (60221595)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 自己免疫疾患 / 自己寛容 / 胸腺髄質上皮細胞 / 中枢性寛容 / 自己抗原 / 胸腺 / Aire |
Outline of Final Research Achievements |
Medullary thymic epithelial cells (mTECs) are a heterogeneous population in terms of the spectrum of tissue-restricted antigens (TRAs) expressed from each cell for ensuring the elimination of autoreactive T-cells. Because of these heterogeneities, it is unclear whether mTECs are composed of any particular subsets possessing unique properties for their developmental pathway and/or immunological function. Here, we report a distinct mTEC subset characterized by expression of Ly6 family protein. Ly6C/6G+ mTECs, constituting 5-15% of mature mTECs, were preferentially localized at the cortico-medullary junction, and expressed high levels of TRAs. Remarkably, Ly6C/6G+ mTECs were absent in Aire-deficient mice, suggesting that this subset requires Aire and/or Aire+ mTECs for its production. We suggest that Ly6C/6G+ mTECs serve as an important source of TRAs for efficient cross-presentation during establishment of self-tolerance.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla.2015
Author(s)
Nishijima H, Kitano S, Miyachi H, Morimoto J, Kawano H, Hirota F, Morita R, Mouri Y, Masuda K, Imoto I, Ikuta K, Matsumoto M.
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Journal Title
Journal of Immunology
Volume: 195
Pages: 4641-4649
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Syndecan 4 Regulation of the Development of Autoimmune Arthritis in Mice by Modulating B Cell Migration and Germinal Center Formation.2015
Author(s)
Endo T, Ito K, Morimoto J, Kanayama M, Ota D, Ikesue M, Kon S, Takahashi D, Onodera T, Iwasaki N, Uede T.
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Journal Title
Arthritis Rheumatology
Volume: 67
Pages: 2512-2522
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Tumor-a9b1 integrin-mediated signaling induces breast cancer growth and lymphatic metastasis via the recruitment of cancer-associated fibroblasts.2014
Author(s)
Ota D, Kanayama M, Matsui Y, Ito K, Maeda N, Kutomi G, Hirata K, Torigoe T, Sato N, Takaoka A, Chambers AF, Morimoto J, Uede T.
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Journal Title
Journal of Molecular Medicine
Volume: 92
Pages: 1271-1281
DOI
Related Report
Peer Reviewed
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[Journal Article] Integrin a9 on lymphatic endothelial cells regulates lymphocyte egress.2014
Author(s)
Ito K, Morimoto J, Kihara A, Matsui Y, Kurotaki D, Kanayama M, Shimmons S, Ishii M, Sheppard D, Takaoka A, Uede T.
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Journal Title
Proceedings of the National Academy of Sciences
Volume: 111
Pages: 3080-3085
DOI
Related Report
Peer Reviewed / Open Access
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