| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Recent studies have drawn attention to a nuclear protein HMGA2, abundantly expressed in the mesenchyme, as a differentiation marker in epithelial tumor cells. In this study, we demonstrated selective expression of HMGA2 in malignant tumor tissues, among various types of thyroid tissue, by using immuno-histochemical staining (IHC). Our results raised a possibility that the IHC of HMGA2 in surgical specimens of follicular thyroid cancer brings about more reliable diagnosis, differentiated from benign follicular adenoma, as well as prediction of its prognosis. In addition, our transcriptome analysis in thyroid cancer cell lines supported our hypothesis that pathogenic variants of thyroglobulin promote tumor development through the induction of HMGA2 followed by several oncogenic gene expressions.
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