FGF23-Klotho is associated with the progression of a disease of aging matter lesions
Project/Area Number |
26460751
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Epidemiology and preventive medicine
|
Research Institution | Kyoto Prefectural University of Medicine |
Principal Investigator |
OZAKI ETSUKO 京都府立医科大学, 医学(系)研究科(研究院), 助教 (00438219)
|
Co-Investigator(Kenkyū-buntansha) |
渡辺 能行 京都府立医科大学, 医学(系)研究科(研究院), 教授 (00191809)
渡邉 功 京都府立医科大学, 医学(系)研究科(研究院), 助教 (10636525)
松井 大輔 京都府立医科大学, 医学(系)研究科(研究院), 助教 (20613566)
栗山 長門 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60405264)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | FGF23 / BAP / UCAR / non-CKD / TRACP-5b / 骨代謝 |
Outline of Final Research Achievements |
We investigated whether Phosphate (P) load into circulation might cause renal damage in non-CKD women. This cross-sectional study included 1,094 non-CKD Japanese women. Fibroblast growth factors (FGF)-23 as the parameters for P load, bone alkaline phosphatase (BAP) as the bone metabolic marker, and urinary albumin-to-creatinine ratio (UACR) as an early marker for renal damage were measured. Postmenopausal women exhibited significantly higher levels of serum P, FGF-23, BAP, and UACR and significantly lower eGFR than in premenopausal women. In premenopausal women, although serum FGF-23 failed to correlate with log UACR, multiple regression analysis elucidate FGF-23 to associate significantly in a positive manner with log UACR. In postmenopausal women, multiple regression analysis confirmed the significant and independent association between serum BAP and log UACR.
|
Report
(4 results)
Research Products
(5 results)
-
[Journal Article] Association between loss of bone mass due to short sleep and leptin-sympathetic nervous system activity2017
Author(s)
Nagato Kuriyama, Masaaki Inaba, Etsuko Ozaki, Yutaro Yoneda, Daisuke Matsui, Kanae Hashiguchi, Teruhide Koyama, Komei Iwai, Isao Watanabe, Rika Tanaka, Chie Omichi, Shigeto Mizuno, Masao Kurokawa, Motoyuki Horii, Fumitoshi Niwa, Koichi Iwasa, Shinsuke Yamada, Yoshiyuki Watanabe
-
Journal Title
Archives of Gerontology and Geriatrics
Volume: 70
Pages: 201-208
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-