| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
TRAIL is a promising anti-cancer agent but has still been going on clinical studies. To improve the TRAIL efficacy, I carried out the screening of food factors which could induce endogenous TRAIL expression and the analysis of the induction mechanism. Then, I found a marine carotenoid, a flavonoid, an isothiocyanate and a metabolite of fatty acid as TRAIL inducers. In addition, I found two low-molecular weight compounds except for food factors also up-regulated TRAIL expression. I elucidated the mechanism by which the fatty acid metabolite induced TRAIL expression. A transcription factor RUNX1 interacted with IRF1 and collaborated with it to up-regulation of TRAIL expression at the transcription level.
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