Development of rapid and simple diagnostic assays for 10 food poisoning bacteria and viruses using monoclonal antibodies

• Project/Area Number: 26460807
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hygiene and public health
• Research Institution: University of Hyogo
• Principal Investigator: Kitamoto Noritoshi 兵庫県立大学, 環境人間学部, 教授 (70145928)
• Co-Investigator(Kenkyū-buntansha): 加藤 陽二 兵庫県立大学, 環境人間学部, 教授 (30305693)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 単クローン抗体 / 感染型食中毒 / 毒素型食中毒 / 下痢症ウイルス / 迅速簡便診断法 / イムノクロマト法 / 食中毒 / 迅速簡便診断 / 迅速簡便鑑別診断法

Outline of Final Research Achievements

Monoclonal antibodies (MAbs) are powerful tools for the study of microorganism. A panel of MAbs against food poisoning bacteria and viruses would be valuable for the development of rapid, simple and specific diagnostic assays such as Enzyme-linked immunosorbent assay (ELISA) and immunochromatography (IC) applied for multiple samples. We obtained 8 MAbs to each bacterium, enterotoxigenic Escherichia coli, Salmonella enteritidis, Vibrio parahaemolyticus, Campylobacter jejuni, Verotoxin producing Escherichia coli, Staphylococcus aureus, Clostridium perfringens and Bacillus cereus. We confirmed these MAbs were specific to each bacterium by an ELISA test and IC. The IC is and will make it possible to screen for and detect food poisoning in most of laboratories or institutes.

Research Products

• [Int'l Joint Research] Baylor College of Medicine(米国)
• [Journal Article] Size-controlled preparation of peroxidase-like graphene-gold nanoparticle hybrids for the visible detection of norovirus-like particles (2017)
  • Author(s): Syed Rahin Ahmed, Kenshin Takemura, Tian-Cheng Li, Noritoshi Kitamoto, Tomoyuki Tanaka, Tetsuro Suzuki, and Enoch Y. Park
  • Journal Title: Biosens. Bioelectron Volume: 87 Pages: 558-565
  • DOI: 10.1016/j.bios.2016.08.101
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 腸管出血性大腸菌（ベロ毒素産生菌）は河川源流・上流にも存在する (2017)
  • Author(s): 北元憲利,加藤陽二
  • Journal Title: 人間と環境 Volume: 43(1) Pages: 35-39
  • NAID: 40021105308
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Characterization of monoclonal antibody against syringate derivatives: application of immunochemical detection of methyl syringate in honey (2016)
  • Author(s): Yoji Kato, Rie Fujinaka, Maki Juri, Yui Yoshiki, Akari Ishisaka, Noritoshi Kitamoto, Yoko Nitta, and Hirohito Ishikawa
  • Journal Title: J. Agric. Food Chem Volume: 64 Issue: 33 Pages: 6495-501
  • DOI: 10.1021/acs.jafc.6b01328
  • Peer Reviewed / Open Access
• [Journal Article] A novel quinone derived from 5-hydroxyindoleacetic acid reacts with protein: Possible participation of oxidation of serotonin and its metabolite in the development of atherosclerosis. (2016)
  • Author(s): Kato Y, Oki K, Suga N, Ono S, Ishisaka A, Miura Y, Kanazawa S, Naito M, Kitamoto N, Kettle AJ
  • Journal Title: Free Radic. Biol. Med. Volume: 101 Pages: 500-510
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Competitive immunochromatographic assay for leptosperin as a plausible authentication marker of manuka honey. (2016)
  • Author(s): Yoji Kato, Yukako Araki, Maki Juri, Akari Ishisaka, Yoko Nitta, Toshio Niwa, Noritoshi Kitamoto, Yosuke Takimoto
  • Journal Title: Food Chemistry Volume: 194 Pages: 362-365
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inhibition of Morganella morganii Histidine Decarboxylase Activity and Histamine Accumulation in Mackerel Muscle Derived from Filipendula ulumaria Extracts. (2016)
  • Author(s): Nitta Y, Yasukata F, Kitamoto N, Ito M, Sakaue M, Kikuzaki H, Ueno H
  • Journal Title: Journal of Food Protection Volume: 79 Issue: 3 Pages: 463-7
  • DOI: 10.4315/0362-028x.jfp-15-313
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Characterization of cross-reactive norovirus-specific monoclonal antibodies. (2015)
  • Author(s): Baijun Kou, Sue E. Crawford, Nadim J. Ajami, Rita Czakó, Frederick H. Neill, Tomoyuki N. Tanaka, Noritoshi Kitamoto, Timothy G. Palzkill, Mary K. Estes, Robert L. Atmar
  • Journal Title: Clinical and Vaccine Imuunology Volume: Vol.22 Issue: 2 Pages: 160-167
  • DOI: 10.1128/cvi.00519-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Mapping Broadly Reactive Norovirus Genogroup I and II Monoclonal Antibodies. (2015)
  • Author(s): Sue E. Crawford, Nadim Ajami, Tracy Dewese Parker, Noritoshi Kitamoto, Katsurou Natori, Naokazu Takeda, Tomoyuki Tanaka, Baijun Kou, Robert L. Atmar, and Mary K. Estes
  • Journal Title: Clinical and Vaccine Imuunology Volume: Vol.22 Issue: 2 Pages: 168-177
  • DOI: 10.1128/cvi.00520-14
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Plausible authentication of manuka honey and related products by measuring leptosperin with methyl syringate. (2014)
  • Author(s): Yoji Kato, Rie Fujinaka, Akari Ishisaka, Yoko Nitta*, Noritoshi Kitamoto, Yosuke Takimoto
  • Journal Title: J. Agric. Food Chem. Volume: 62(27) Issue: 27 Pages: 6400-6407
  • DOI: 10.1021/jf501475h
  • Peer Reviewed / Open Access
• [Journal Article] Covalent modification of cytoskeletal proteins in neuronal cells by tryptamine 4,5-dione (2014)
  • Author(s): Yoji Kato, Shigeki Ono, Noritoshi Kitamoto, Anthony J. Kettle
  • Journal Title: Redox Biology Volume: 2 Pages: 983-990
  • DOI: 10.1016/j.redox.2014.08.004
  • Peer Reviewed / Open Access
• [Journal Article] Immunochemical authentication of manuka honey using a monoclonal antibody specific to a glycoside of methyl syringate (2014)
  • Author(s): Yoji Kato, Yukako Araki, Maki Juri, Rie Fujinaka, Akari Ishisaka, Noritoshi Kitamoto, Yoko Nitta, Toshio Niwa, Yosuke Takimoto,
  • Journal Title: J. Agric. Food Chem Volume: 62 Issue: 44 Pages: 10672-10678
  • DOI: 10.1021/jf503464a
  • Peer Reviewed / Open Access
• [Journal Article] Scavenger receptor CL-P1 mediates endocytosis by associating with AP-2μ2. (2014)
  • Author(s): Jang S, Ohtani K, Fukuoh A, Mori K, Yoshizaki T, Kitamoto N, Kim Y, Suzuki Y, Wakamiya N.
  • Journal Title: Biochim Biophys Acta. Volume: 1840(11) Issue: 11 Pages: 734-734
  • DOI: 10.1016/j.bbagen.2014.07.019
  • Peer Reviewed / Open Access
• [Presentation] 種々の食中毒細菌の同時・鑑別・迅速診断法の可能性 (2016)
  • Author(s): 北元憲利,加藤陽二
  • Organizer: 日本感染症学会西日本・中日本地方学会・合同総会
  • Place of Presentation: 沖縄コンベンションセンター（沖縄県宜野湾市真志喜）
  • Year and Date: 2016-11-24
• [Presentation] レプトスペリンおよびメチルシリンゲートの吸収代謝機構の解析 (2016)
  • Author(s): 加藤陽二,石坂朱里,竹内美栄,荒木裕佳子,河合慶親,北元憲利,室田佳恵子,石川大仁,生城真一
  • Organizer: 第21回日本フードファクター学会
  • Place of Presentation: 富山県立大学（富山県射水市黒河）
  • Year and Date: 2016-11-19
• [Presentation] マヌカ蜂蜜摂取によるレプトスペリンおよびメチルシリンゲート代謝のLC-MS/MS解析 (2016)
  • Author(s): 石坂朱里,生城真一,重里真希,吉木結以,河合慶親,北元憲利,石川大仁,加藤陽二
  • Organizer: 第21回日本フードファクター学会
  • Place of Presentation: 富山県立大学（富山県射水市黒河）
  • Year and Date: 2016-11-19
• [Presentation] 3T3-L1細胞における小豆および白インゲン豆煮汁の脂肪蓄積抑制作 (2016)
  • Author(s): 中 愛里,石坂朱里,北元憲利,村上 明,加藤陽二
  • Organizer: 第21回日本フードファクター学会
  • Place of Presentation: 富山県立大学（富山県射水市黒河）
  • Year and Date: 2016-11-19
• [Presentation] セロトニン酸化物Tryptamine-4,5-dioneによる神経細胞毒性と保護効果 (2016)
  • Author(s): 菅 尚子,村上 明,中村宜督,石坂朱里,北元憲利,伊藤美紀子,加藤陽二
  • Organizer: フードサイエンスフォーラム（FSF）
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市北区津島）
  • Year and Date: 2016-09-08
• [Presentation] セロトニン由来キノン体Tryptamine-4,5-dioneによる神経細胞毒性と保護効果 (2016)
  • Author(s): 菅 尚子,村上 明,中村宜督,石坂朱里,北元憲利,伊藤美紀子,加藤陽二
  • Organizer: 第69回日本酸化ストレス学会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市北区津島）
  • Year and Date: 2016-08-30
• [Presentation] 兵庫県内河川上流で分離された大腸菌およびサルモネラ菌の遺伝子学的検討 (2016)
  • Author(s): 北元憲利,加藤陽二
  • Organizer: 第42回日本環境学会
  • Place of Presentation: 東京都市大学横浜キャンパス（神奈川県横浜市都築区）
  • Year and Date: 2016-06-18
• [Presentation] ニュージーランド産ベリー類の抗炎症作用の検討 (2016)
  • Author(s): 中西礼治,石坂朱里,北元憲利,加埜康博,石川大仁,加藤陽二
  • Organizer: 第21回日本フードファクター学会
  • Place of Presentation: 富山県立大学（富山県射水市黒河）
• [Presentation] Formation and metabolism of N-hexanoyl and propanoyl-phosphatidylethanolamine adducts, (2015)
  • Author(s): Miho Hirakawa, Akari Ishisaka, Noritoshi Kitamoto, Akira Murakami, Yoji Kato
  • Organizer: 7th Joint Meeting of the Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: University of Otago (Anzac Avenue, Dunedin), New Zealand
  • Year and Date: 2015-12-07
  • Int'l Joint Research
• [Presentation] Modification of cellular proteins and induction of self-defense genes expressions by tryptamine-4,5-dione, a serotonin oxidation product (2015)
  • Author(s): Naoko Suga, Akari Ishisaka, Noritoshi Kitamoto, Mikiko Ito, Akira Murakami, Yoshimasa Nakamura, Yoji Kato
  • Organizer: 7th Joint Meeting of the Societies for Free Radical Research Australasia and Japan
  • Place of Presentation: University of Otago (Anzac Avenue, Dunedin), New Zealand
  • Year and Date: 2015-12-07
  • Int'l Joint Research
• [Presentation] Immunochemical detections for leptosperin as an authentication marker of manuka honey (2015)
  • Author(s): Yoji Kato, Yukako Araki, Maki Juri, Akari Ishisaka, Yoko Nitta, Toshio Niwa, Noritoshi Kitamoto, Hirohito Ishikawa
  • Organizer: The 6th International Conference on Food Factors (ICoFF 2015)
  • Place of Presentation: COEX (Yeongdong-daero, Grangnam-gu,Seoul), Republic of Korea
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Effect of quinone derived from 5-Hydroxytryptamine on expression of genes in SH-SY5Y neuroblastoma cells (2015)
  • Author(s): Naoko Suga, Akari Ishisaka, Noritoshi Kitamoto, Akira Murakami, Yoshimasa Nakamura, Yoji Kato
  • Organizer: The 6th International Conference on Food Factors (ICoFF 2015)
  • Place of Presentation: COEX (Yeongdong-daero, Grangnam-gu,Seoul), Republic of Korea
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Reaction of food-derived isothiocyanate, benzyl-isothiocyanate, with aminophospholipid (2015)
  • Author(s): Miho Hirakawa, Akari Ishisaka, Noritoshi Kitamoto, Akira Murakami, Yoshimasa Nakamura, Yoji Kato
  • Organizer: The 6th International Conference on Food Factors (ICoFF 2015)
  • Place of Presentation: COEX (Yeongdong-daero, Grangnam-gu,Seoul), Republic of Korea
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Inhibitory effect of boysenberry on lipid accumulation in cultured cells (2015)
  • Author(s): Reiji Nakanishi, Akari Ishisaka, Noritoshi Kitamoto, Yasuhiro Kano, Hirohito Ishikawa, Yoji Kato
  • Organizer: The 6th International Conference on Food Factors (ICoFF 2015)
  • Place of Presentation: COEX (Yeongdong-daero, Grangnam-gu,Seoul), Republic of Korea
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Preventive effect of herbs on allergy-like food poisoning (2015)
  • Author(s): Fumiko Yasukata, Noritoshi Kitamoto, Yoji Kato, Akari Ishisaka, Akira Murakami, Yoko Nitta
  • Organizer: The 6th International Conference on Food Factors (ICoFF 2015)
  • Place of Presentation: COEX (Yeongdong-daero, Grangnam-gu,Seoul), Republic of Korea
  • Year and Date: 2015-11-22
  • Int'l Joint Research
• [Presentation] Anthocyanin, cyanidin 3-sophoroside, has suppressive effects on inflammatory responses (2015)
  • Author(s): Reiji Nakanishi, Akari Ishisaka, Noritoshi Kitamoto, Yasuhiro Kano, Hirohito Ishikawa, Yoji Kato：Anthocyanin, cyanidin 3-sophoroside, has suppressive effects on inflammatory responses
  • Organizer: 7th International Conference on Polyphenol and Health, ICPH2015
  • Place of Presentation: Congress Center Tours (Place Francols Truffacot,Tour) France.
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] Deconjugation of quercetin metabolites at sites of inflammation (2015)
  • Author(s): Akari Ishisaka, Yoji Kato, Noritoshi Kitamoto, Junji Terao, Yoshichika Kawai
  • Organizer: 7th International Conference on Polyphenol and Health, ICPH2015
  • Place of Presentation: Congress Center Tours (Place Francols Truffacot,Tour) France.
  • Year and Date: 2015-10-27
  • Int'l Joint Research
• [Presentation] ハーブを用いたアレルギー様食中毒発生予防法の検討 (2015)
  • Author(s): 安方芙実子,北元憲利,加藤陽二,新田陽子
  • Organizer: 第62回日本栄養改善学会
  • Place of Presentation: 福岡国際会議場（福岡市博多区石城町）
  • Year and Date: 2015-09-24
• [Presentation] なる不法投棄地点により分離された大腸菌群の菌種の比較 (2015)
  • Author(s): 北元憲利,安方芙実子,加藤陽二
  • Organizer: 第41回日本環境学会
  • Place of Presentation: 龍谷大学深草キャンパス（京都市伏見区深草塚本町）
  • Year and Date: 2015-06-20
• [Presentation] セロトニン関連物質に由来するキノン体による細胞タンパク質修飾及び遺伝子発現に与える影響 (2015)
  • Author(s): 菅尚子，石坂朱里，北元憲利，中村宜督, 加藤陽二
  • Organizer: 日本酸化ストレス学会
  • Place of Presentation: 鹿児島県民交流センター（鹿児島市山下町）
  • Year and Date: 2015-06-11
• [Presentation] 脂質酸化に伴うN-アシル化修飾フォスファチジルエタノールアミンの生成と代謝 (2015)
  • Author(s): 平川実保, 石坂朱里, 北元憲利, 加藤陽二
  • Organizer: 日本酸化ストレス学会
  • Place of Presentation: 鹿児島県民交流センター（鹿児島市山下町）
  • Year and Date: 2015-06-11
• [Presentation] ボイセンベリーに含まれるアントシアニンの抗炎症作用 (2015)
  • Author(s): 中西礼治, 石坂朱里, 北元憲利, 加埜康博, 瀧本陽介, 加藤陽二
  • Organizer: 日本酸化ストレス学会
  • Place of Presentation: 鹿児島県民交流センター（鹿児島市山下町）
  • Year and Date: 2015-06-11
• [Presentation] 配糖体Leptosperinの免疫化学的検出によるマヌカ蜂蜜の認証評価 (2015)
  • Author(s): 加藤陽二, 荒木裕佳子, 重里真希, 藤中里衣, 石坂朱里, 北元憲利, 新田陽子, 丹羽利夫, 瀧本陽介
  • Organizer: 2015年度日本農芸化学会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市津島）
  • Year and Date: 2015-03-27 – 2015-03-29
• [Presentation] セロトニン由来キノン体のヒトLDL修飾と細胞への作用 (2015)
  • Author(s): 菅尚子, 石坂朱里, 北元憲利, 中村宜督, 加藤陽二
  • Organizer: 2015年度日本農芸化学会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市津島）
  • Year and Date: 2015-03-27 – 2015-03-29
• [Presentation] ハーブを用いたアレルギー様食中毒発生予防法の検討 (2015)
  • Author(s): 安方芙実子, 北元憲利, 加藤陽二, 石坂朱里, 新田陽子
  • Organizer: 2015年度日本農芸化学会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市津島）
  • Year and Date: 2015-03-27 – 2015-03-29
• [Presentation] 腐敗菌および食品付着細菌に対する塩麹の抗菌効果について (2015)
  • Author(s): 北元憲利, 高橋香澄, 安方芙実子, 石坂朱里, 加藤陽二, 新田陽子, 相良純一, 尾関健二
  • Organizer: 2015年度日本農芸化学会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市津島）
  • Year and Date: 2015-03-27 – 2015-03-29
• [Presentation] 3T3-L1細胞を用いたボイセンベリーによる抗肥満作用の解析 (2014)
  • Author(s): 中西礼治, 石坂朱里, 菅尚子, 北元憲利, 加埜康博, 瀧本陽介, 加藤陽二
  • Organizer: 第19回日本フードファクター学会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島県鹿児島市郡元）
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] 配糖体Leptosperinのモノクローナル抗体作成とマヌカ蜂蜜認証評価への応用 (2014)
  • Author(s): 荒木裕佳子, 重里真希, 藤中里衣, 石坂朱里, 瀧本陽介, 北元憲利, 新田陽子, 丹羽利夫,加藤陽二
  • Organizer: 第19回日本フードファクター学会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島県鹿児島市郡元）
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] セロトニン由来キノン体のタンパク質修飾阻害 (2014)
  • Author(s): 菅尚子, 小野成輝, 石坂朱里, 北元憲利, 加藤陽二
  • Organizer: 第19回日本フードファクター学会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島県鹿児島市郡元）
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] アミノリン脂質に対するイソチオシアネート付加修飾の検出定量 (2014)
  • Author(s): 平川実保, 木田真衣, 石坂朱里, 北元憲利, 中村宜督, 加藤陽二
  • Organizer: 第19回日本フードファクター学会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島県鹿児島市郡元）
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] 豆類煮汁は3T3-L1細胞における脂肪蓄積を抑制する, (2014)
  • Author(s): 石坂朱里, 中西礼治, 北元憲利, 加藤陽二
  • Organizer: 第19回日本フードファクター学会
  • Place of Presentation: 鹿児島大学郡元キャンパス（鹿児島県鹿児島市郡元）
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] リポソーム酸化に伴うN-hexanoyl及びN-propanoyl修飾フォスファチジルエタノールアミンの生成 (2014)
  • Author(s): 平川実保，山下瑞紀，尾上麻衣，石坂朱里，北元憲利, 加藤陽二
  • Organizer: 第67回日本酸化ストレス学会
  • Place of Presentation: 同志社大学今出川キャンパス（京都府京都市上京区）
  • Year and Date: 2014-09-04 – 2014-09-05
• [Presentation] セロトニン関連物質に由来するキノン体による細胞内チオールへの影響 (2014)
  • Author(s): 菅尚子，小野成輝，石坂朱里，北元憲利，Anthony Kettle, 加藤陽二
  • Organizer: 第67回日本酸化ストレス学会
  • Place of Presentation: 同志社大学今出川キャンパス（京都府京都市上京区）
  • Year and Date: 2014-09-04 – 2014-09-05
• [Book] 休み時間の微生物学（第2版） (2016)
  • Author(s): 北元憲利
  • Total Pages: 213
  • Publisher: 講談社サイエンテフィク
• [Book] もっと知りたい 微生物大図鑑 ①なぞがいっぱいウイルスの世界 (2015)
  • Author(s): 北元憲利
  • Total Pages: 40
  • Publisher: ミネルヴァ書房
• [Book] もっと知りたい 微生物大図鑑 ②ヒントがいっぱい細菌の利用価値 (2015)
  • Author(s): 北元憲利
  • Total Pages: 40
  • Publisher: ミネルヴァ書房
• [Book] もっと知りたい 微生物大図鑑 ③ふしぎがいっぱい真菌と寄生虫 (2015)
  • Author(s): 北元憲利
  • Total Pages: 40
  • Publisher: ミネルヴァ書房
• [Book] のぞいてみようウイルス・細菌・真菌図鑑～ウイルスのひみつ～ (2014)
  • Author(s): 北元憲利
  • Total Pages: 40
  • Publisher: ミネルヴァ社
• [Book] のぞいてみようウイルス・細菌・真菌図鑑～細菌のはたらき～ (2014)
  • Author(s): 北元憲利
  • Total Pages: 40
  • Publisher: ミネルヴァ社
• [Book] のぞいてみようウイルス・細菌・真菌図鑑～真菌の不思議～ (2014)
  • Author(s): 北元憲利
  • Total Pages: 40
  • Publisher: ミネルヴァ社