Correspondence analysis of gene expressions in hypothermic adrenal gland, heart, kidney, liver, and lung using DNA microarray
| Project/Area Number |
26460884
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Legal medicine
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三枝 聖 岩手医科大学, 教養教育センター, 講師 (30398490)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 低体温症 / 肝臓 / 肺 / DNA microarray / quantitative PCR / 対応分析 / DNAマイクロアレイ / 定量PCR / 相関分析 / DNA microarray法 / 定量PCR法 / 免疫染色法 / 心臓 / 腎臓 / トランスクリプトーム |
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| Outline of Final Research Achievements |
We analyzed the hepatic and pulmonary transcriptome of mice killed by hypothermia using DNA microarray technology. The present study demonstrated acute hepatic and pulmonary responses in hypothermia, and we suggest that understanding hepatic and pulmonary mRNA expression would be useful for hypothermia diagnosis. Furthermore, the present microarray data may facilitate development of immunohistochemical analyses that could be used for human autopsies. Corresponding analyses were also performed concerning to gene expressions in hypothermic adrenal gland, heart, kidney, liver, and lung. These analyses would reveal relationships among these organs in hypothermia.
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Report
(4 results)
Research Products
(3 results)
