The elucidation and clinical application of the effect of vestibular stimulation on the imbalance of dementia patients

• Project/Area Number: 26460901
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: University of Tsukuba
• Principal Investigator: Nakamagoe Kiyotaka 筑波大学, 医学医療系, 講師 (10436272)
• Co-Investigator(Kenkyū-buntansha): 玉岡 晃 筑波大学, 医学医療系, 教授 (50192183) ; 小金澤 禎史 筑波大学, 医学医療系, 助教 (80431691)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 認知症 / バランス障害 / 転倒予防 / 前庭刺激 / アルツハイマー病 / エア・カロリック装置 / 温度眼振検査 / 電気眼振図検査 / 前頭側頭葉変性症 / 前庭皮質 / 追従眼球障害 / 前頭側頭葉型認知症 / 平衡機能検査 / バランス / 前庭中枢 / 大脳

Outline of Final Research Achievements

Elderly people with dementia usually fall easily due to balance disorders. We reported that vestibular dysfunction due to cerebral cortex disorder could be related to balance disorders with Alzheimer's disease (AD). In this study, we attempted to induce vestibular compensation due to vestibular stimulation, which can activate the cerebrum, such as the vestibular cortex, with the intention of preventing the progress of balance disorders. We used an air caloric device to repeat vestibular stimulation in patients with AD every two weeks for six months. Their dementia symptoms progressed over the observation period; on the other hand, based on subjective symptoms and objective tests, such as electronystagmography and caloric testing, there was no meaningful indication that the balance disorder was progressing. The possibility that vestibular stimulation could delay the progression of balance disorders with AD was suggested from these results.

Research Products

• [Journal Article] Upbeat nystagmus is a useful sign in the regional diagnosis of trigeminal nerve disorder with multiple sclerosis (2018)
  • Author(s): Nakamagoe K, Tozaka N, Nohara S, Kawakami R, Yamada S, Koganezawa T, Tamaoka A
  • Journal Title: Mult Scler Relat Disord Volume: 19 Pages: 59-61
  • DOI: 10.1016/j.msard.2017.11.008
  • NAID: 120007134428
  • Peer Reviewed
• [Journal Article] Hemolytic Uremic Syndrome-associated Encephalopathy Successfully Treated with Corticosteroids (2017)
  • Author(s): Hosaka T, Nakamagoe K, Tamaoka A
  • Journal Title: Internal Medicine Volume: 56 Issue: 21 Pages: 2937-2941
  • DOI: 10.2169/internalmedicine.8341-16
  • NAID: 130006191943
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] The Successful Application of Plasmapheresis in the Treatment of a Patient with Opsoclonus and Autoantibodies to Glutamate Receptor δ2 (2017)
  • Author(s): Nakamagoe K, Nohara S, Takahashi Y, Takiguchi M, Kawakami R, Koganezawa T, Tamaoka A
  • Journal Title: Internal Medicine Volume: 56 Issue: 20 Pages: 2773-2778
  • DOI: 10.2169/internalmedicine.6771-15
  • NAID: 130006856742
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Chronic Graft-versus-host Disease Presenting with Multiple Punctate Intracranial Lesions on Contrast-enhanced Magnetic Resonance Imaging (2017)
  • Author(s): Terada M, Nakamagoe K, Obara N, Ogawa S, Sakamoto N, Sato T, Nohara S, Chiba S, Tamaoka A.
  • Journal Title: Internal Medicine Volume: 56 Issue: 3 Pages: 363-368
  • DOI: 10.2169/internalmedicine.56.7329
  • NAID: 130005310315
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] Vestibular Impairment in Frontotemporal Dementia Syndrome (2016)
  • Author(s): Nakamagoe K, Kadono K, Koganezawa T, Takiguchi M, Terada M, Yamamoto F, Moriyama T, Yanagiha K, Nohara S, Tozaka N, Miyake Z, Aizawa S, Furusho K, Tamaoka A.
  • Journal Title: Dement Geriatr Cogn Dis Extra. Volume: 6 Issue: 2 Pages: 194-204
  • DOI: 10.1159/000445870
  • NAID: 120007129376
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Adult-onset Krabbe disease presenting as acute hemiparesis and progressive demyelination detected by diffusion-weighted imaging (2016)
  • Author(s): Mamada N, Nakamagoe K, Shioya A, Furuta J, Sakai N, Ishii A, Tamaoka A.
  • Journal Title: J Neurol Sci. Volume: 367 Pages: 326-328
  • DOI: 10.1016/j.jns.2016.06.026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A case of very-long-chain acyl-coenzyme A dehydrogenase deficiency with novel compound heterozygous mutations (2016)
  • Author(s): 7) Yamamoto F, Nakamagoe K, Yamada K, Ishii A, Furuta J, Yamaguchi S, Tamai A
  • Journal Title: Journal of the Neurological Sciences Volume: 368 Pages: 165-167
  • DOI: 10.1016/j.jns.2016.07.007
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vestibular impairment in frontotemporal dementia syndrome (2016)
  • Author(s): Nakamagoe K, Kadono K, Koganezawa T, Takiguchia M, Terada M, Yamamoto F, Moriyama T, Yanagiha K, Nohara S, Toozaka N, Miyake Z, Aizawa S, Furusho K, Tamaoka A
  • Journal Title: Dementia and Geriatric Cognitive Disorders Extra Volume: 未定
  • NAID: 120007129376
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Opsoclonus associated with autoantibodies to glutamate receptors δ2 (2015)
  • Author(s): Hosaka T, Nakamagoe K, Takahashi Y, Mamada N, Tamaoka A
  • Journal Title: Neurological Sciences Volume: 36 Issue: 9 Pages: 1741-1742
  • DOI: 10.1007/s10072-015-2264-4
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Immunohistochemical characterization of CD33 expression on microglia in Nasu-Hakola disease brains. (2015)
  • Author(s): Satoh J, Kino Y, Motohashi N, Ishida T, Yagishita S, Jinnai K, Arai N, Nakamagoe K, Tamaoka A, Saito Y, Arima K
  • Journal Title: Neuropathology Volume: 35 Issue: 6 Pages: 529-537
  • DOI: 10.1111/neup.12222
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Vestibular function impairment in Alzheimer’s disease (2015)
  • Author(s): Nakamagoe K, Fujimiya M, Koganezawa T, Shimizu K, Fujizuka N, Tamaoka A
  • Journal Title: Journal of Alzheimer’s Disease Volume: 47 Issue: 1 Pages: 185-196
  • DOI: 10.3233/jad-142646
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains. (2014)
  • Author(s): Satoh J, Motohashi N, Kino Y, Ishida T, Yagishita S, Jinnai K, Arai N, Nakamagoe K, Tamaoka A, Saito Y, Arima K.
  • Journal Title: Orphanet J Rare Dis Volume: 9 Issue: 1 Pages: 1-11
  • DOI: 10.1186/1750-1172-9-68
  • Peer Reviewed / Open Access
• [Journal Article] 【神経症候群(第2版)-その他の神経疾患を含めて-】 脊髄・脊椎疾患、髄液動態異常 Brown-Sequard症候群(解説/特集) (2014)
  • Author(s): 中馬越 清隆
  • Journal Title: 日本臨床 (0047-1852)別冊神経症候群 Volume: V Pages: 139-143
  • Peer Reviewed
• [Journal Article] 先行感染後にopsoclonus-myoclonus syndromeを認め、髄液中の抗GluRδ2抗体とGluRε2抗体が陽性であった1例 (2014)
  • Author(s): 保坂 孝史, 儘田 直美, 中馬越 清隆, 石井 一弘, 高橋 幸利, 玉岡 晃
  • Journal Title: 運動障害 Volume: 24 Pages: 1-6
  • Peer Reviewed
• [Presentation] Abnormal saccadic intrusions without visual fixation in Alzheimer's disease (2017)
  • Author(s): Kiyotaka Nakamagoe; Rio Kawakami; Tadachika Koganezawa; Shiori Yamada; Akira Tamaoka
  • Organizer: XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] アルツハイマー病における滑動性眼球運動 (2016)
  • Author(s): 中馬越清隆
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県 神戸市h）
• [Presentation] アルツハイマー病の経過における前庭機能異常 (2015)
  • Author(s): 中馬越清隆
  • Organizer: 第56回 日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ
  • Year and Date: 2015-05-23
• [Presentation] アルツハイマー病に置けるバランス機能の検討について (2014)
  • Author(s): 中馬越清隆ら
  • Organizer: 第５５回 日本神経学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-21
• [Book] 臨床医・RI技師のための脳 SPECTパーフェクトガイド (2018)
  • Author(s): 監修：松田博史、編集：玉岡晃、柴田靖、根本清貴、著者：玉岡晃、中馬越清隆他
  • Total Pages: 352
  • Publisher: メディカ出版