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Defense system against viral infection by maoto through the enhancement of autophagy

Research Project

Project/Area Number 26460929
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionFukuoka University

Principal Investigator

Nabeshima Shigeki  福岡大学, 医学部, 教授 (50304796)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsインフルエンザ / 麻黄湯 / オートファジー / 炎症性サイトカイン / アポトーシス / エンドゾーム / インフルエンザウイルス / 漢方薬 / V-ATPase / ライソゾーム / インフラマゾーム
Outline of Final Research Achievements

This study was objected to clarify the anti-virus mechanism of maoto, the TraditionalJapanese herbal medicine, through autophagy. In vitro study of influenza virus infection showed that influenza caused the disfunction of autophagy and indued apoptosis. Maoto canncelled these disfunction of infected cells. Taken together, maoto strongly reduced the inflammatory cytokines, such as IL1 beta and Il-6 induced by infection through normalizing the autophagy. We also found that maoto inhibited the uncoating of influenza virus by inhibiting the acidification of endosomes, resulting in the blocking of influenza virus infection.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Maoto, a Traditional Japanese Herbal Medicine, Inhibits Uncoating of Influenza Virus2017

    • Author(s)
      Shinta Masui, Shigeki Nabeshima,Kazuhiko Ajisaka, Kei Yamauchi,Ryota Itoh, Kazunari Ishii, Toshinori Soejima,and Kenji Hiromatsu
    • Journal Title

      Evidence-Based Complementary and Alternative Medicine

      Volume: 2017 Issue: 1 Pages: 1-12

    • DOI

      10.1155/2017/1062065

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] インフルエンザと麻黄湯ー自然免疫系への影響と抗ウイルスメカニズムー2017

    • Author(s)
      鍋島茂樹
    • Organizer
      日本東洋医学会沖縄県部会
    • Place of Presentation
      沖縄県
    • Year and Date
      2017-02-04
    • Related Report
      2016 Research-status Report
  • [Presentation] 麻黄湯によるインフルエンザ感染防御機構に解析2016

    • Author(s)
      鍋島茂樹、増井信太、鰺坂和彦
    • Organizer
      日本感染症学会総会
    • Place of Presentation
      宮城県
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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