| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
The translocation of tumor necrosis factor alfa (TNF-a) amino terminal fragment (TNF-a-NTF) in colon cells and tissues obtained from patients with ulcerative colitis was investigated. IL-8 induced ADAM 17 activation, resulting the shedding of proTNF-a, and acetate suppressed the activation of ADAM 17. The translocation of TNF-a-NTF into the cell nucleus was caused by the activation of ADAM 17. However, angiotensin II receptor blocker (ARB) suppressed the translocation of TNF-a-NTF into the cell nucleus. TNF-a-NTF and ADAM 17 were expressed in colon epithelial cells. The expression of ADAM 17 in colon epithelial cells of patients with ulcerative colitis were higher than that in normal colon epithelial cells. The inhibition of TNF-a-NTF nuclear translocation signaling will comprise a new strategy against the development of ulcerative colitis. TNF-a-NTF might become one of the targets of future strategies to treat ulcerative colitis.
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