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Non-celiac gluten sensitivity and celiac disease

Research Project

Project/Area Number 26460980
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionNational Defense Medical College

Principal Investigator

Watanabe Chikako  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 内科学, 講師 (90365263)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords下部消化管学 / 粘膜免疫 / セリアック病 / グルテン / 過敏性腸症 / 輸送体 / トランスポーター
Outline of Final Research Achievements

Celiac disease is precipitated, in genetically predisposed persons, by the ingestion of gluten, resulting in mucosal inflammation and villous atrophy.
“non-celiac gluten sensitivity” is a syndrome characterized by intestinal symptoms related to the ingestion of gluten-containing food, without enteropathy. Not only celiac disease but non-celiac gluten sensitivity sometimes share the similar symptoms to those in irritable bowel syndrome, being possibly misdiagnosed.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2017 2016 2015 Other

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Neutrophil trafficking to microvessels is largely enhanced by PepT1 mediated bacterial peptide transport in TNF-alpha-challenged murine colonic mucosa in vivo.2016

    • Author(s)
      Chikako Watanabe, Ryota Hokari, Soichiro Miura
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: 31 Pages: 441-441

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Endoscopic and clinical evaluation of treatment and prognosis of Cronkhite-Canada syndrome: a Japanese nationwide survey.2016

    • Author(s)
      Watanabe C, Komoto S, Tomita K, Hokari R, Tanaka M, Hirata I, Hibi T, Kaunitz JD, Miura S
    • Journal Title

      Journal of Gastroenterology

      Volume: 51 Issue: 4 Pages: 327-336

    • DOI

      10.1007/s00535-015-1107-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Upregulation of PEPT1 and muramyl dipeptide transport may stimulates neutrophil trafficking in LPS-induced colonic inflammation2017

    • Author(s)
      Chikako Watanabe, Ryota Hokari, Soichiro Miura
    • Organizer
      DDW 2017
    • Place of Presentation
      Chicago
    • Year and Date
      2017-05-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Celiac病の実態の臨床調査2016

    • Author(s)
      渡辺知佳子、白壁和彦、東山正明、高本俊介、冨田謙吾、穂苅量太、三浦総一郎
    • Organizer
      消化吸収学会
    • Place of Presentation
      神戸
    • Year and Date
      2016-11-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 消化管ポリポーシス疾患クロンカイト・カナダ症候群における消化管腫瘍・小腸病変について2016

    • Author(s)
      渡辺知佳子 穂苅量太 三浦総一郎
    • Organizer
      小腸研究会 第54回
    • Place of Presentation
      大宮
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Neutrophil trafficking to microvessels is largely enhanced by PepT1 mediated bacterial peptide transport in TNF-alpha-challenged murine colonic mucosa in vivo.2016

    • Author(s)
      Chikako Watanabe Soichiro Miura, Ryota Hokari
    • Organizer
      Asian Pacific Digestive Week
    • Place of Presentation
      Kobe
    • Year and Date
      2016-11-04
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neutrophil trafficking to microvessels is largely enhanced by PepT1 mediated bacterial peptide transport in TNF-alpha-challenged murine colonic mucosa in vivo2016

    • Author(s)
      Chikako Watanabe Soichiro Miura, Ryota Hokari
    • Organizer
      DDW2016
    • Place of Presentation
      San Diego
    • Year and Date
      2016-05-23
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neutrophil trafficking to microvessels is largely enhanced by PepT1 mediated bacterial peptide transport in TNF-alpha-challenged murine colonic mucosa in vivo.2016

    • Author(s)
      Chikako Watanabe et al
    • Organizer
      米国消化器病学会DDW2016
    • Place of Presentation
      米国サンディエゴ国際会議場
    • Year and Date
      2016-05-22
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 消化管ポリポーシス疾患、とくにクロンカイト・カナダ症候群における消化管腫瘍・小腸病変について2015

    • Author(s)
      いわて県民情報交流センター
    • Organizer
      第53回小腸研究会
    • Place of Presentation
      いわて県民情報交流センター
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
  • [Presentation] クロンカイト・カナダ症候群の治療における栄養療法2015

    • Author(s)
      穂苅量太 高本俊介 渡辺知佳子 東山正明 三浦総一郎
    • Organizer
      第12回日本在宅静脈経腸栄養研究会学術集会
    • Place of Presentation
      名古屋市立大学病院講堂
    • Year and Date
      2015-10-03
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Cronkhite-Canada症候群の臨床経過2015

    • Author(s)
      渡辺知佳子
    • Organizer
      消化管ポリポーシス研究会
    • Place of Presentation
      仙台国際会議場
    • Year and Date
      2015-04-25
    • Related Report
      2015 Research-status Report
  • [Book] ガイドライン準拠 消化器病診療マニュアル2017

    • Author(s)
      渡辺知佳子 三浦総一郎
    • Total Pages
      999
    • Publisher
      中山書店
    • Related Report
      2015 Research-status Report
  • [Book] 消化器研修医ノート改定第2版2016

    • Author(s)
      渡辺 知佳子, 穂苅 量太, 三浦 総一郎
    • Total Pages
      664
    • Publisher
      診断と治療社
    • Related Report
      2016 Annual Research Report
  • [Book] 消化器研修ノート2016

    • Author(s)
      渡辺知佳子
    • Total Pages
      664
    • Publisher
      診断と治療会社
    • Related Report
      2015 Research-status Report
  • [Book] 《プリンシプル消化器疾患の臨床》シリーズ、今日の腸疾患診療2016

    • Author(s)
      渡辺知佳子 三浦総一郎
    • Total Pages
      999
    • Publisher
      中山書店
    • Related Report
      2015 Research-status Report
  • [Remarks] 難治性炎症性腸管障害に関する調査研究

    • URL

      http://www.ibdjapan.org/ccs/members/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 難病情報センター

    • URL

      http://www.nanbyou.or.jp/entry/4607

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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