| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Over the past several decades, significant progress has been made in the pathohistological assessment of vulnerable plaques and in invasive intravascular imaging techniques. However, the assessment of plaque morphology by invasive modalities is of limited value for the detection of subclinical coronary atherosclerosis and the subsequent prediction or prevention of acute cardiovascular events. Following the introduction of noncontrast T1-weighted imaging (T1WI) on magnetic resonance (MR), some investigators have reported that coronary artery high-intensity signals (HISs) on T1WI are associated with vulnerable plaque morphology and an increased risk of future cardiac events. We showed that the presence of HISs on T1WI was a novel independent predictor of the no-reflow phenomenon during percutaneous coronary intervention (PCI) in angina patients, and that thrombus-related HIS at the target lesions was identified as an independent predictor of major adverse cardiovascular events after PCI.
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