Elucidation of the role of mast cell chymase in salt-dependent hypertension
| Project/Area Number |
26461118
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Fukuoka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 心臓病態学 / 高血圧 / 食塩過剰摂取 / マウス / キマーゼ / アンジオテンシンⅡ |
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| Outline of Final Research Achievements |
Establishment of a salt-dependent moderate hypertension mouse model was confirmed, namely, 2% NaCl concentration in drinking water for 3 months increased blood pressure up to 146 / 100 mmHg. Depressor effect of chymase inhibitors and various antihypertensive drugs were challenged and we found that complete depressor effect of a specific chymase inhibitor was confirmed in salt dependent hypertensive mice model. Chymase inhibitors showed dose-dependent antihypertensive and heart rate reduction. On the other hand, among existing antihypertensive drugs, only angiotensin receptor antagonist and aldosterone receptor antagonists slightly, but significantly, reduced blood pressure. The tissue chymase activity was increased in the gastrointestinal tract, skin, and skeletal muscle. Those results proved that increased tissue chymase activity with high salt loading contributed to hypertension and activated sympathetic nervous system.
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Report
(4 results)
Research Products
(3 results)
