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The effects of left ventricular unloading on cardiomyocyte regeneration

Research Project

Project/Area Number 26461128
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular medicine
Research InstitutionNagoya University

Principal Investigator

UNNO Kazumasa  名古屋大学, 医学部附属病院, 助教 (40709119)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords心筋細胞 / 細胞分裂 / 多倍体細胞 / 心筋細胞分裂 / 核内受容体 / エピゲノム修飾 / 単核心筋細胞 / 核酸合成 / 内因性心筋再生 / 心筋再生
Outline of Final Research Achievements

Over the last decade, increasing evidence has suggested that the adult mammalian heart exhibits regenerative capacity due to proliferation of existing cardiomyocytes. It is unclear, however, if external stress may reactivate or upregulate the endogenous cardiac regenerative capacity. Acute left ventricle pressure overload was produced by constriction of ascending aorta (AAC) in adult mouse hearts. One week following AAC, ventricular afterload was normalized in a subset of animal through removal of the aortic constriction (de-AAC). Interestingly, acute decrease in ventricular overload with de-AAC was marked by an increase in cardiomyocyte proliferation. Those cardiomyocytes positive for thymidine analog labeling were characteristic of newly generated cardiomyocytes, with smaller size and single diploid nuclei. Moreover, newly generated cardiomyocytes were found to reside in close proximity to one another, consistent with regional stimulation of cellular proliferation.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2014

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Corticotropin releasing hormone receptor 2 exacerbates chronic cardiac dysfunction.2017

    • Author(s)
      Tsuda T, Takefuji M, Wettschureck N, Kotani K, Morimoto R, Okumura T, Kaur H, Eguchi S, Sakaguchi T, Ishihama S, Kikuchi R, Unno K, Matsushita K, Ishikawa S, Offermanns S, Murohara T.
    • Journal Title

      J Exp Med.

      Volume: 214 Issue: 7 Pages: 1877-1877

    • DOI

      10.1084/jem.20161924

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diallyl Trisulfide Augments Ischemia-Induced Angiogenesis via an Endothelial Nitric Oxide Synthase-Dependent Mechanism2017

    • Author(s)
      Hayashida R, Kondo K, Morita S, Unno K, Shintani S, Shimizu Y, Calvert JW, Shibata R, Murohara T.
    • Journal Title

      Circulation Journal

      Volume: 81 Issue: 6 Pages: 870-878

    • DOI

      10.1253/circj.CJ-16-1097

    • NAID

      130005679693

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] A Transient Up-regulation of Aldh1a2/RARs /Wif-1 Axis Induces Cell-cycle Arrest in Neonatal Heart2018

    • Author(s)
      Fujikawa Y, Unno K, Murohara T
    • Organizer
      BCBR
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Transient Up-regulation of Retinoic Acid Signaling Induces Cell-Cycle Arrest in Neonatal Mammalian Heart2017

    • Author(s)
      Yusuke Fujikawa, Kazumasa Unno, Shingo Narita, Ryo Hayashida, Kazuhisa Kondo, Mikito Takefuji, Toyoaki Murohara.
    • Organizer
      AHA Annual Meeting
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Book] 循環器内科学2014

    • Author(s)
      海野一雅、室原豊明、以下省略
    • Total Pages
      516
    • Publisher
      科学評論社
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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