Cross-talk between uppper and lower airway involvenet assesed by CT imaging and biomarkers in asthmatic subjects

• Project/Area Number: 26461151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Hokkaido University
• Principal Investigator: Konno Satoshi 北海道大学, 医学研究科, 准教授 (20399835)
• Co-Investigator(Kenkyū-buntansha): 清水 薫子 北海道大学, 大学病院, 特任助教 (40399853)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 気管支喘息 / バイオマーカー / 副鼻腔病変

Outline of Final Research Achievements

This study was aimed aim to evaluate the effect of smoking on the relationship
between sinus involvement and asthma-related indices. Resuts from this study showed that sinusitis and asthma are expressions of a common process characterized by intense Th2-related inflammation,regardless of smoking status. However, such Th2-related inflammation may be linked withfixed airflow limitation only in non-smoking asthmatics.

Research Products

• [Journal Article] Sinus Computed Tomographic Findings in Adult Smokers and Nonsmokers with Asthma. Analysis of Clinical Indices and Biomarkers. (2017)
  • Author(s): Kimura H, et al
  • Journal Title: Ann Am Thorac Soc Volume: 14 Issue: 3 Pages: 332-341
  • DOI: 10.1513/annalsats.201606-463oc
  • Peer Reviewed / Open Access
• [Journal Article] Contrasting associations of body mass index and measles with asthma and rhinitis in young adults (2015)
  • Author(s): Kimura H, Konno S, Isada A, Maeda Y, Musashi M, Nishimura M
  • Journal Title: Allergy Asthma Proc Volume: 36 Issue: 4 Pages: 293-299
  • DOI: 10.2500/aap.2015.36.3837
  • Peer Reviewed
• [Journal Article] Distinct Phenotypes of Cigarette Smokers Identified by Cluster Analysis of Patients with Severe Asthma (2015)
  • Author(s): Konno S, Taniguchi N, Makita H, Nakamaru Y, Shimizu K, Shijubo N, Fuke S, Takeyabu K, Oguri M, Kimura H, Maeda Y, Suzuki M, Nagai K, Ito YM, Wenzel SE, Nishimura M
  • Journal Title: Ann Am Thorac Soc Volume: 12 Issue: 12 Pages: 1771-1780
  • DOI: 10.1513/annalsats.201507-407oc
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] Sinus Computed Tomographic Findings in Adult Smokers and Nonsmokers with Asthma. Analysis of Clinical Indices and Biomarkers (2016)
  • Author(s): Kimura H, Konno S, et al.
  • Organizer: Am Thorac Soc International Conference
  • Place of Presentation: 米国 サンフランシスコ
  • Year and Date: 2016-05-15
  • Int'l Joint Research
• [Presentation] 喘息患者における副鼻腔CT所見とその関連因子 (2015)
  • Author(s): 木村孔一，今野哲，中丸裕爾，牧田比呂仁，谷口菜津子，清水薫子，鈴木雅，西村正治
  • Organizer: 第64回日本アレルギー学会学術大会
  • Place of Presentation: 新高輪プリンスホテル(東京都,港区)
  • Year and Date: 2015-05-26
• [Presentation] Sinus Computed Tomographic Findings in Asthmatics: Comparison between Mild-to-moderate and Severe Asthma and Associations with Asthma-related Indices (2015)
  • Author(s): Kimura H, Konno S, Nakamaru Y, Makita H, Taniguchi N, Shimizu K, Suzuki M, Nishimura M
  • Organizer: The 110th American Thoracic Society International Conference
  • Place of Presentation: Colorado convention center (Denver, USA)
  • Year and Date: 2015-05-20
  • Int'l Joint Research
• [Presentation] Associations of serum periostin level with sinusitis severity and persistent airflow limitation in severe asthma (2014)
  • Author(s): Kimura H, Konno S, Nakamaru Y, Makita H, Taniguchi N, Shimizu K, Maeda Y, Suzuki M, Nagai K, Ono J, Izuhara K, Nishimura M.
  • Organizer: The 109th American Thoracic SccietyInternational Conference
  • Place of Presentation: San Diego Convention Center (San Diedo, USA)
  • Year and Date: 2014-05-21
• [Presentation] 難治性喘息患者における血清ペリオスチン濃度と呼吸機能・副鼻腔陰影重症度との関連 (2014)
  • Author(s): 木村孔一、今野 哲、中丸裕爾、牧田比呂仁、谷口菜津子、清水薫子、前田由起子、鈴木雅、長井桂、小野純也、太田昭一郎、出原賢治、西村正治
  • Organizer: 第26回日本アレルギー学会春季臨床大会
  • Place of Presentation: 国立京都国際会館（京都市）
  • Year and Date: 2014-05-09