Prefrontal cortex activation is associated with dyspnea during methacholine bronchial provocation tests

• Project/Area Number: 26461171
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kindai University
• Principal Investigator: HIGASHIMOTO Yuji 近畿大学, 医学部, 講師 (70316115)
• Co-Investigator(Kenkyū-buntansha): 本田 憲胤 公益財団法人田附興風会, 医学研究所 第12研究部, 研究員 (10724156)
• Co-Investigator(Renkei-kenkyūsha): TOHDA Yuji 近畿大学, 医学部, 教授 (50167524)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 呼吸困難感 / 気管支喘息 / 気道過敏性検査 / 脳皮質活動 / 呼吸困難 / 近赤外線分光法 / 脳皮質血流

Outline of Final Research Achievements

We previously reported that exertional dyspnea was related to activation (oxygenation) of the prefrontal cortex in COPD patients and control subjects. However, it is unknown which activated brain area is associated with this symptom in patients with bronchial asthma.To investigate the activation of cortical areas associated with dyspnea during methacholine bronchial provocation tests. Thirteen asthma patients and six control subjects underwent methacholine bronchial provocation tests.Cerebral hemodynamics and oxygenation were determined by near-infrared spectroscopy (NIRS). Changes from baseline recordings of cortical oxyhemoglobin (Oxy-Hb) concentrations were measured. Increased oxy-Hb (oxygenation) was assumed to reflect cortical activation.
Results: Cortical activation was detected in the right prefrontal area in all subjects during their sensation of dyspnea.Prefrontal cortex activation is associated with dyspnea during methacholine bronchial provocation tests.

Research Products

• [Journal Article] Physical activity in daily life in patients with idiopathic pulmonary fibrosis (2018)
  • Author(s): Nishiyama Osamu、Yamazaki Ryo、Sano Hiroyuki、Iwanaga Takashi、Higashimoto Yuji、Kume Hiroaki、Tohda Yuji
  • Journal Title: Respir Investig Volume: 56 Issue: 1 Pages: 57-63
  • DOI: 10.1016/j.resinv.2017.09.004
  • Peer Reviewed
• [Journal Article] 【息切れのリハビリテーション】 慢性閉塞性肺疾患の息切れの機序とそれに対するリハビリテーション (2017)
  • Author(s): 東本有司
  • Journal Title: The Japanese Journal of Rehabilitation Medicine Volume: 54 Pages: 965-968
  • Peer Reviewed
• [Journal Article] 【花粉症研究の進歩】 咳,下気道に関する研究 (2017)
  • Author(s): 東本有司、東田有智
  • Journal Title: アレルギー・免疫 Volume: 24 Pages: 350-355
• [Journal Article] Clinical Features and Outcomes of IPF Patients Hospitalized for Pulmonary Infection: A Japanese Cohort Study (2017)
  • Author(s): Yamazaki, R. Nishiyama, O. Sano, H. Iwanaga, T. Higashimoto, Y. Kume, H. Tohda, Y.
  • Journal Title: PLoS One Volume: 11 Issue: 12 Pages: e0168164-e0168164
  • DOI: 10.1371/journal.pone.0168164
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary Hemodynamics and Six-Minute Walk Test Outcomes in Patients with Interstitial Lung Disease (2017)
  • Author(s): Nishiyama, O. Yamazaki, R. Sano, H. Iwanaga, T. Higashimoto, Y. Kume, H. Tohda, Y.
  • Journal Title: Can Respir J Volume: 2016 Pages: 1-6
  • DOI: 10.1155/2016/3837182
  • Peer Reviewed
• [Journal Article] Fat-free mass index predicts survival in patients with idiopathic pulmonary fibrosis (2016)
  • Author(s): Nishiyama, O. Yamazaki, R. Sano, H. Iwanaga, T. Higashimoto, Y. Kume, H. Tohda, Y.
  • Journal Title: Respirology Volume: 22 Issue: 3 Pages: 480-485
  • DOI: 10.1111/resp.12941
  • Peer Reviewed
• [Journal Article] Characteristics of phenotypes of elderly patients with asthma (2016)
  • Author(s): Sano, H. Iwanaga, T. Nishiyama, O. Sano, A. Higashimoto, Y. Tomita, K. Tohda, Y.
  • Journal Title: Allergology International Volume: 65 Issue: 2 Pages: 204-209
  • DOI: 10.1016/j.alit.2015.11.007
  • NAID: 130005149292
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Prognostic value of forced expiratory volume in 1 second/forced vital capacity in idiopathic pulmonary fibrosis (2016)
  • Author(s): Nishiyama, O. Yamazaki, R. Sano, A. Yamagata, T. Sano, H. Iwanaga, T. Higashimoto, Y. Kume, H. Tohda, Y.
  • Journal Title: Chron Respir Dis Volume: 13 Issue: 1 Pages: 40-7
  • DOI: 10.1177/1479972315603714
  • Peer Reviewed
• [Journal Article] Influence of comorbidities on the efficacy of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (2016)
  • Author(s): Higashimoto, Y. Yamagata, T. Maeda, K. Honda, N. Sano, A. Nishiyama, O. Sano, H. Iwanaga, T. Chiba, Y. Fukuda, K. Tohda, Y.
  • Journal Title: Geriatr Gerontol Int Volume: 16 Issue: 8 Pages: 934-41
  • DOI: 10.1111/ggi.12575
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Effect of a postoperative outpatient pulmonary rehabilitation program on physical activity in patients who underwent pulmonary resection for lung cancer (2016)
  • Author(s): Maeda, K. Higashimoto, Y. Honda, N. Shiraishi, M. Hirohata, T. Minami, K. Iwasaki, T. Chiba, Y. Yamagata, T. Terada, K. Matsuo, Y. Shuntoh, H. Tohda, Y. Fukuda, K.
  • Journal Title: Geriatr Gerontol Int Volume: 16 Issue: 5 Pages: 550-5
  • DOI: 10.1111/ggi.12505
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Exertional dyspnoea and cortical oxygenation in patients with COPD (2015)
  • Author(s): Higashimoto Y, Honda N, Yamagata T, Sano A, Nishiyama O, Sano H, Iwanaga T, Kume H, Chiba Y, Fukuda K, Tohda Y
  • Journal Title: The European respiratory journal Volume: 46 Issue: 6 Pages: 1615-1624
  • DOI: 10.1183/13993003.00541-2015
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Influence of hypoxemia on cognitive function and cortex activation in COPD patients (2015)
  • Author(s): ：杉谷 竜司, 大城 昌平, 東本 有司, 前田 和成, 白石 匡, 岡島 聡, 山縣 俊之, 寺田 勝彦, 東田 有智, 福田 寛二
  • Journal Title: The Journal of the Japan Society for Respiratory Care and Rehabilitation Volume: 25 Issue: 3 Pages: 457-461
  • DOI: 10.15032/jsrcr.25.3_457
  • NAID: 130005123271
  • ISSN: 1881-7319, 2189-4760
  • Peer Reviewed
• [Journal Article] Relation between physical activity and depression score in patients with COPD, before and after outpatient pulmonary rehabilitation program. (2015)
  • Author(s): 白石 匡, 東本 有司, 本田 憲胤, 前田 和成, 岡島 聡, 杉谷 竜司, 西山 理, 山縣 俊之, 寺田 勝彦, 東田 有智, 福田 寛二
  • Journal Title: The Journal of the Japan Society for Respiratory Care and Rehabilitation Volume: 25 Issue: 3 Pages: 384-388
  • DOI: 10.15032/jsrcr.25.3_384
  • NAID: 130005123281
  • ISSN: 1881-7319, 2189-4760
  • Peer Reviewed
• [Journal Article] 【外来で出会う呼吸器common疾患】 呼吸器系のcommon疾患 気管支喘息 診断と外来でのマネジメント (2015)
  • Author(s): 東本 有司, 東田 有智
  • Journal Title: Medicina Volume: 52 Pages: 1538-1541
• [Presentation] 肺切除術施行患者に対し、在宅呼吸リハビリテーションが有効であった一症例 (2017)
  • Author(s): 岡島, 章子, 前田, 和成, 富沢, 健二, 東本, 有司, 岡島, 聡, 井関, 歩, 地案, 菜月, 白石, 匡, 岸本, 英樹 光冨, 徹哉
  • Organizer: 日本呼吸ケア・リハビリテーション学会
• [Presentation] COPD患者の運動時脳皮質酸素化と呼吸困難感の関連 (2015)
  • Author(s): 東本 有司, 本田 憲胤, 杉谷 竜司, 白石 匡, 岡島 聡, 前田 和成, 沖本 奈美, 山縣 俊之, 西山 理, 東田 有智
  • Organizer: 日本呼吸ケア・リハビリテーション学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2015-10-15
• [Presentation] 性閉塞性肺疾患の呼吸リハビリテーションの効果に対する背景因子と加齢の影響 (2015)
  • Author(s): 東本有司
  • Organizer: 日本老年病学会学術集会
  • Place of Presentation: パシフィコ横浜 （横浜）
  • Year and Date: 2015-06-12
• [Presentation] Exertional Dyspnoea And Cerebral Oxygenation In Patients With Chronic Obstructive Pulmonary Disease (2015)
  • Author(s): Higashimoto Y, Honda N, Yamagata T, Sano A, Nishiyama O, Sano H, Iwanaga T, Kume H, Chiba Y, Fukuda K, Tohda Y
  • Organizer: America Thoracic Society International Conference
  • Place of Presentation: Colorado Convention Center(Denver, CO, USA)
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] Ralationship Between Physical Activity and Depression in Patients with COPD Participating in an Outpatient Pulmonary Rehabilitation Program (2015)
  • Author(s): Masashi Shiraishi, Yuji Higashimoto, Kazushige Maeda, Satoshi Okajima, Ryuji Sugiya, , Osamu Nishiyama, Yuji Tohda, Kanji Fukuda, Yuko Sawada, Toshiyuki Yamagata, Katsuhiko Terada
  • Organizer: America Thoracic Society International Conference
  • Place of Presentation: Colorado Convention Center(Denver, CO, USA)
  • Year and Date: 2015-05-16
  • Int'l Joint Research
• [Presentation] COPD患者における運動時脳皮質酸素化と呼吸困難の関連 (2015)
  • Author(s): 東本 有司, 沖本 奈美, 山縣 俊之, 佐野 安紀子, 西山 理, 佐野 博幸, 岩永 賢司, 久米 裕明, 東田 有智
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京）
  • Year and Date: 2015-04-17
• [Presentation] COPDの呼吸リハビリテーションの効果に関連する合併症と背景因子の検討 (2014)
  • Author(s): ：東本 有司, 山縣 俊之, 沖本 奈美, 前田 和成, 白石 匡, 杉谷 竜司, 岡島 聡, 西山 理, 福田 寛二, 東田 有智
  • Organizer: 日本呼吸ケア・リハビリテーション学会学術集会
  • Place of Presentation: なら100年会館
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] 肺癌による肺切除後の日常活動量に及ぼす加齢の影響と外来リハビリテーションの効果 (2014)
  • Author(s): 東本 有司
  • Organizer: 日本老年病学会総会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2014-06-12 – 2014-06-14
• [Presentation] 肺癌における肺切除後の日常活動量に及ぼす外来リハビリテーションの効果 (2014)
  • Author(s): 東本 有司, 岸本 恵美理, 上田 昌美, 豊増 麻美, 福田 寛二
  • Organizer: 日本リハビリテーション医学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-06-05 – 2014-06-07
• [Book] 診療ガイドラインUp-to-date (2014)
  • Author(s): 東本有司、東田有智
  • Total Pages: 935
  • Publisher: メディカルビユー社