Development of new intestinal phosphorus control in CKD-MBD treatment
| Project/Area Number |
26461254
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokushima |
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Principal Investigator |
SEGAWA Hiroko 徳島大学, 大学院医歯薬学研究部(医学系), 講師 (70325257)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | リン / 腸 / 腎臓 / CKD-MBD / 腸管 / リン酸 / AKP / トランスポーター |
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| Outline of Final Research Achievements |
In patients with chronic kidney disease (CKD), inorganic phosphate (Pi) retention leads to secondary hyperparathyroidism, uremic bone disease, cardiovascular calcification, and progression to end-stage renal disease. Inorganic phosphate (Pi) homeostasis is primarily regulated by the small intestine functions in Pi absorption, the kidney functions in Pi excretion, and bone acts as a Pi reservoir. The mechanism of intestinal Pi absorption, however, is still unknown. Previous reports suggested that Intestinal Alkaline phosphatases (IAP) regulate gut homeostasis and health. It is not clear that IAP is involved in the gastrointestinal Pi homeostasis. In the present study, we examined Pi homeostasis in IAP null mice. Intestinal Pi transport activity and transporter expression levels were significantly lower in IAP KO mice than WT mice. Furthermore, IAP KO mice showed higher levels of blood 1,25(OH)2D3 levels than WT mice. In conclusion, IAP may involve the gastrointestinal Pi homeostasis.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Niacin and Chronic Kidney Disease2015
Author(s)
Taketani Y, Masuda M, Yamanaka-Okumura H, Tatsumi S, Segawa H, Miyamoto K, Takeda E, Yamamoto H.
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Journal Title
Journal of Nutritional Science and Vitaminology
Volume: 61
Issue: Supplement
Pages: S173-S175
DOI
NAID
ISSN
0301-4800, 1881-7742
Related Report
Peer Reviewed / Open Access
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[Journal Article] Effect of dietary components on renal inorganic phosphate (Pi) excretion induced by a Pi-depleted diet.2014
Author(s)
Ohnishi R, Segawa H, Ohmoto T, Sasaki S, Hanazaki A, Mori A, Ikuta K, Furutani J, Kawakami E, Tatsumi S, Hamada Y, Miyamoto K
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Journal Title
J Med Invest
Volume: 61
Pages: 162-170
NAID
Related Report
Peer Reviewed
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[Presentation] 消化管リン輸送機構の役割2017
Author(s)
瀬川博子, 宮本賢一
Organizer
日本農芸化学会2017年度大会
Place of Presentation
京都女子大学（京都府京都市）
Year and Date
2017-03-18
Related Report
Invited
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[Presentation] 形態の異なるリン化合物接種に対する生体への影響2016
Author(s)
川端優佳, 瀬川博子, 結城志帆子, 中山彰吾, 藤井公, 生田かよ, 花崎愛, 野津圭二郎, 西口詩織, 金子一郎, 辰巳佐和子, 宮本賢一.
Organizer
第70回日本栄養食糧学会大会
Place of Presentation
武庫川女子大学（兵庫県西宮市）
Year and Date
2016-05-13
Related Report
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[Presentation] Genetic deletion of NaPi-2c rescue phenotype of klotho knockout mice without improving severe hyperphosphatemia2015
Author(s)
Ai Hanazaki, Hiroko Segawa, Kayo Ikuta, Toru Fujii, Ichiro Kaneko, Shihoko Yuki, Shiori Nishiguchi, Keijiro Notsu, Yuji Shiozaki, Sawako Tatsumi, Ken-ichi Miyamoto
Organizer
米国腎臓学会, kidney week 2015
Place of Presentation
San Diego Convention Center（米国・カリフォルニア州・サンディエゴ市）
Year and Date
2015-11-03
Related Report
Int'l Joint Research
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[Presentation] Disruption of intestinal alkaline phosphatase (Akp3) affects the phosphate homeostasis2015
Author(s)
Shihoko Yuki, Hiroko Segawa, Shohei Sasaki, Kayo Ikuta, Ichiro Kaneko, Toru Fujii, Ai Hanazaki, Shiori Nishiguchi, Keijiro Notsu, Eriko Aki, Yuji Shiozaki, Sawako Tatsumi, Ken-ichi Miyamoto
Organizer
ACN2015 12th Asian Congress of Nutrition
Place of Presentation
PACIFIKO Yokohama, Yokohama, Japan
Year and Date
2015-05-14 – 2015-05-18
Related Report
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[Presentation] Disruption of intestinal alkaline phosphatase (Akp3) affects the phosphate homeostasis.2015
Author(s)
Shihoko Yuki, Hiroko Segawa, Shohei Sasaki, Kayo Ikuta, Ichiro Kaneko, Toru Fujii, Ai Hanazaki, Shiori Nishiguchi, Keijiro Notsu, Eriko Aki, Yuji Shiozaki, Sawako Tatsumi, Ken-ichi Miyamoto.
Organizer
ACN2015 Asian Congress of Nutrition.
Place of Presentation
パシフィコ横浜（神奈川県、横浜市）
Year and Date
2015-04-14
Related Report
Int'l Joint Research
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