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Mechanism of transplanted adipose tissue stem cells isolated from omentum promoting tissue repair in injured peritoneum

Research Project

Project/Area Number 26461260
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionJuntendo University

Principal Investigator

HAMADA Chieko  順天堂大学, 医学部, 准教授 (50291662)

Research Collaborator Hara Kazuaki  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords腹膜透析 / 組織再生 / 細胞移植 / 細胞形質転換 / 組織線維化 / 抗酸化物質 / 線維化 / 形質転換 / 脂肪幹細胞
Outline of Final Research Achievements

Transplanted mesothelial cells into peritoneal cavity aggravated peritoneal injury while progressing peritoneal fibrosis and infiltrating inflammatory cells. However, adipose tissue stem cells (ADSCs) suppressed fibrosis and promote peritoneal repair. Mesothelial cells (MCs) pre-treated with anti-oxidative agent showed resistant to stimulation (peritoneal dialysate) derive epithelial-mesothelial transition (EMT) and production of inflammatory cytokines and growth factors. Furthermore, EMT and production of inflammatory cytokines and growth factors were suppressed in co-culture of ADSCs and MCs under stimulation, and supernatant derived from stimulated ADSCs also inhibited EMT in mesothelial cells against peritoneal dialysate. These results suggested that endocrine effect of ADSCs to mesothelial cells, component cells in peritoneum one of mechanism to promote tissue repair in injured peritoneum.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015

All Presentation (9 results) (of which Int'l Joint Research: 4 results)

  • [Presentation] Crosstalk between adipose tissue stem cells and mesothelial cells in epithelial-mesenchymal transition (EMT).2017

    • Author(s)
      Chieko Hamada
    • Organizer
      The 8th APCM-ISPD 2017
    • Place of Presentation
      広州、中国
    • Year and Date
      2017-03-22
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 腹膜中皮細胞における抗酸化物質アスタキサンチンの上皮間葉転換抑制に関する検討2016

    • Author(s)
      原 一彰, 濱田 千江子, 若林 啓一, 神田 怜生, 井尾 浩章, 金子 佳代, 堀越 哲
    • Organizer
      第59回日本腎臓学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Impact of oxidative stress on epithelial-mesenchymal transition in mesothelial cells isolated from temperature-sensitive SV40 large T-antigen gene transgenic rats2016

    • Author(s)
      Kazuaki Hara, Chieko Hamada, Keiichi Wakabasyahi, Reo Kanda, Hiroaki Io, Satoshi Horikoshi
    • Organizer
      The 58th ERA-EDTA
    • Place of Presentation
      ウィーン、オーストリア
    • Year and Date
      2016-05-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IMPACT OF OXIDATIVE STRESS ON EPITHELIAL-MESENCHYMAL TRANSITION IN MESOTHELIAL CELLS ISOLATED FROM TEMPERATURE-SENSITIVE SV40 LARGE T-ANTIGEN GENE TRANSGENIC RATS.2016

    • Author(s)
      137.Kazuaki Hara, Chieko Hamada, Keiichi Wakabayashi, Reo Kanda, Hiroaki Io and Satoshi Horikoshi.
    • Organizer
      第16回国際腹膜透析学会
    • Place of Presentation
      国際会議場(メルボルン、オーストラリア)
    • Year and Date
      2016-02-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] アスタキサンチンは高濃度グルコース環境 下における腹膜中皮細胞の上皮間葉転換 を抑制する2016

    • Author(s)
      原一彰、濱田千江子、若林啓一、神田怜生、金子佳代、堀越哲、富野康 日己、鈴木祐介
    • Organizer
      第7回腎不全研究会
    • Place of Presentation
      東京
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腹膜中皮細胞に対するアスタキサンチンの効果の検討2015

    • Author(s)
      原一彰、濱田千江子
    • Organizer
      日本透析医学会
    • Place of Presentation
      パシフィコ横浜 (日本)
    • Year and Date
      2015-06-26 – 2015-06-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 腹膜中皮細胞に対するアスタキサンチンの抗炎症効果の検討.2015

    • Author(s)
      133.原 一彰, 濱田 千江子, 若林 啓一, 神田 怜生, 中野 貴則, 井尾 浩章, 金子 佳代, 富野 康日己.
    • Organizer
      第60回日本透析医学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2015-06-26
    • Related Report
      2015 Research-status Report
  • [Presentation] Suppressive effect of astaxanthin on epithelial-mesenchymal transition in mesothelial cells isolated from temperature-sensitive SV40 large T-antigen gene transgenic rats2015

    • Author(s)
      原一彰、濱田千江子
    • Organizer
      欧州透析移植学会
    • Place of Presentation
      ロンドン(英国)
    • Year and Date
      2015-05-28 – 2015-05-31
    • Related Report
      2014 Research-status Report
  • [Presentation] SUPPRESSIVE EFFECT OF ASTAXANTIN ON EPITHERIAL MESENCHYMAL TRANSITION IN MESOTHELIAL CELLS ISOLATED FROM TEMPARATURE SENSITIVE SV40 LARGE T ANTIGEN GENE TRANSGENIC RATS.2015

    • Author(s)
      136.Kazuaki Hara, Chieko Hamada, Keiichi Wakabayashi, Reo Kanda, Takanori Nakano, Kayo Kaneko, Hiroaki Io, Satoshi Horikoshi and Yasuhiko Tomino.
    • Organizer
      第52回欧州透析移植学会
    • Place of Presentation
      国際会議場(ロンドン、英国)
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2018-03-22  

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