| Project/Area Number |
26461293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中辻 裕司 大阪大学, 医学系研究科, 准教授 (20332744)
甲田 亨 大阪大学, 医学部附属病院, 医員 (70626134)
多田 智 大阪大学, 微生物病研究所, 招へい研究員 (70626530)
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| Co-Investigator(Renkei-kenkyūsha) |
Hideki Mochizuki 大阪大学, 医学系研究科, 教授 (90230044)
Atsuhi Kumanogoh 大阪大学, 医学系研究科, 教授 (10294125)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 多発性硬化症 / 筋萎縮性側索硬化症 / Sema3E / 虚血 / 低酸素 / 血流 / 神経変性 / セマフォリン / EAE / 血管 / 実験的自己免疫性脳脊髄炎 |
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| Outline of Final Research Achievements |
Multiple Sclerosis(MS) and Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the pathogenesis of which includes ischemia and hypoxia. However, the precise role of hypoxia in neurodegenerative diseases remains unknown. In this study, we administered a synthetic prostacyclin agonist ONO1301, to animal model of ALS (mSOD1G93A mice) to alleviate ischemia and hypoxia in the spinal cord. Prostacyclin agonist successfully suppressed the expression level of HIF1-αin the spinal cords of mSOD1G93A mice, resulting in the significant prevention of neurodegeneration. Our data is the first documented study to suggest that blood flow increasing therapy has a potential to improve neurodegenrative diseases.
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