| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
A β2 agonist clenbuterol specifically up-regulated PGC-1αb/c in skeletal muscle, and the exercise-induced up-regulation of PGC-1αb/c in skeletal muscle was inhibited by a β-adrenergic antagonist propranolol. These data indicate that the β2 adrenergic signaling is responsible for exercise-induced induction of PGC-1αb/c. The expression of PGC-1αb/c induced by clenbuterol was impaired in skeletal muscle of obese model mice. In skeletal muscle of obese animals, the expression of β2 adrenergic receptor (Adrb2) mRNA was decreased and the percentage of methylated CpG sites in the Adrb2 promoter was increased as compared to non-obese mice, suggesting that the epigenetic regulation of Adrb2 likely contributes to the development of adrenaline resistance via the downregulation of Adrb2 in skeletal muscle.
|
