Novel diffusion MRI analyses of brain lesions in children
Project/Area Number |
26461551
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | Aichi Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
早川 昌弘 名古屋大学, 医学部附属病院, 病院教授 (40343206)
青木 茂樹 順天堂大学, 医学部, 教授 (80222470)
池野 充 順天堂大学, 医学部, 助教 (00567985)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 拡散MRI / 拡散カトーシス画像 / 拡散テンソル画像 / 微細構造 / 拡散カトーシス / fractional anisotropy / mean kurtosis / 中枢神経発達 / 早産児 |
Outline of Final Research Achievements |
We performed analyses of microstructural abnormalities of the brain in children with various neurological diseases by using next generation diffusion MRI imaging technique. By applying a 32-axis gradient magnetic field and 3 b values using a 3 Tesla MRI apparatus, we determined the protocol to obtain appropriate diffusion kurtosis images. We attempted to detect microstructural abnormalities of the brain in children with various neurological diseases by means of fractional anisotropy (FA) and mean kurtosis (MK) values as parameters. In particular, many cases of perinatal brain damage could be examined. As a result, there was a resolution limit in diffusion kurtosis images, and it became clear that its detection capability was insufficient. Statistical analysis by tract-based spatial statistics revealed that there is a correlation between MK values and neurological outcome.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Increased fetal heart rate variability in periventricular leukomalacia.2016
Author(s)
Kurahashi H, Okumura A, Kubota T, Kidokoro H, Maruyama K, Hayakawa M, Itakura A, Matsuzawa K, Yamamoto H, Kato T, Hayakawa F, Watanabe K
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Journal Title
Brain & Development
Volume: 38
Issue: 2
Pages: 196-203
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Manifestations and characteristics of congenital adrenal hyperplasia-associated encephalopathy.2016
Author(s)
Abe Y, Sakai T, Okumura A, Akaboshi S, Fukuda M, Haginoya K, Hamano SI, Hirano K, Kikuchi K, Kubota M, Lee S, Maegaki Y, Sanefuji M, Shimozato S, Suzuki M, Suzuki Y, Takahashi M, Watanabe K, Mizuguchi M, Yamanouchi H.
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Journal Title
Brain and Development
Volume: 38
Issue: 7
Pages: 638-647
DOI
Related Report
Peer Reviewed
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[Journal Article] The effects of co-medications on lamotrigine clearance in Japanese children with epilepsy.2016
Author(s)
Takeuchi T, Natsume J, Kidokoro H, Ishihara N, Yamamoto H, Azuma Y, Ito Y, Kurahashi N, Tsuji T, Suzuki M, Itomi K, Yamada K, Kurahashi H, Abe S, Okumura A, Maruyama K, Negoro T, Watanabe K, Kojima S
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Journal Title
Brain Dev
Volume: 38
Issue: 8
Pages: 723-730
DOI
Related Report
Peer Reviewed
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[Journal Article] Medulloblastoma with epithelioid features in the cerebellar vermis.2016
Author(s)
Miyata K, Hori T, Yamakawa K, Takasu M, Hayakawa T, Shimomura Y, Iwata A, Okumura A, Nakura T, Jyoko M, Mori Y, Takahashi E, Hirato J.
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Journal Title
Pediatrics International
Volume: 58
Issue: 9
Pages: 908-912
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Phenotypes of children with 20q13.3 microdeletion affecting KCNQ2 and CHRNA4.2015
Author(s)
Okumura A, Ishii A, Shimojima K, Kurahashi H, Yoshitomi S, lmai K, Imamura M, Seki Y, Shimizu T, Hirose S, Yamamoto T.
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Journal Title
Epileptic Disorders
Volume: 17
Pages: 165-171
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Seizure characteristics of epilepsy in childhood after acute encephalopathy with biphasic seizures and late reduced diffusion.2015
Author(s)
Ito Y, Natsume J, Kidokoro H, Ishihara N, Azuma Y, Tsuji T, Okumura A, Kubota T, Ando N, Saitoh S, Miura K, Negoro T, Watanabe K, Kojima S.
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Journal Title
Epilepsia
Volume: 56
Issue: 8
Pages: 1286-93
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] PET in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome.2014
Author(s)
Natsume J, Maeda N, Itomi K, Kidokoro H, Ishihara N, Takada H, Okumura A, Kubota T, Miura K, Aso K, Morikawa T, Kato K, Negoro T, Watanabe K.
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Journal Title
Am J Neuroradiol.
Volume: 35
Issue: 8
Pages: 1580-5
DOI
Related Report
Peer Reviewed
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[Presentation] 目で見るてんかん2014
Author(s)
奥村彰久
Organizer
第34回日本看護科学学会学術集会
Place of Presentation
名古屋
Year and Date
2014-11-29
Related Report
Invited
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