Assessment for the role and function of Hic-5 in renal fibrosis for the development of treatment in pediatric chronic kidney disease
Project/Area Number |
26461613
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pediatrics
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Research Institution | 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨床研究部(循環器)) (2015-2016) The University of Tokushima (2014) |
Principal Investigator |
Kondo Shuji 独立行政法人国立病院機構四国こどもとおとなの医療センター(臨床研究部(成育)、臨, 小児科, 診療部長 (00380080)
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Co-Investigator(Kenkyū-buntansha) |
香美 祥二 徳島大学, 大学院医歯薬学研究部(医学系), 教授 (00224337)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 腎尿細管間質 / 細胞増殖 / 線維化 / 細胞接着 / 腎線維化 / 小児慢性腎臓病 |
Outline of Final Research Achievements |
Congenital anomalies of the kidney and urinary tract, genetic kidney diseases, and cystic kidney diseases are important diseases for the development of the current therapeutic strategy in pediatric chronic kidney diseases. To develop the novel treatment, the research for renal fibrosis is required. The purpose of the study is to assess the role of Hic-5 on cell injury, proliferation, and accumulation of extracellular matrix in renal fibrosis. The results we obtained are the possible relationship between Hic-5 expression and renal fibrosis in kidney diseases in the human beings and mice. In addition, we demonstrated that the growth inhibitory effect of Hic-5 might improve cell proliferation in acute phase, in contrast, induce fibrosis and sclerosis in chronic phase. A part of the results has been reported in the journal, PLoS One (2015,10:e0122773).
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Report
(4 results)
Research Products
(57 results)
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[Journal Article] Diversity of renal phenotypes in patients with WDR19 mutations: two case reports2017
Author(s)
Yoshikawa T, Kamei K, Nagata H, Saida K, Sato M, Ogura M, Ito S, Miyazaki O, Urushihara M, Kondo S, Sugawara N, Ishizuka K, Hamasaki Y, Shishido S, Morisada N, Iijima K, Nagata M, Yoshioka T, Ogata K, Ishikura K
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Evidence-based clinical practice guidelines for IgA nephropathy 2014.2016
Author(s)
Yuzawa Y, Yamamoto R, Takahashi K, Katafuchi R, Tomita M, Fujigaki Y, Kitamura H, Goto M, Yasuda T, Sato M, Urushihara M, Kondo S, Kagami S, Yasuda Y, Komatsu H, Takahara M, Harabuchi Y, Kimura K, Matsuo S.
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Journal Title
Clin Exp Nephrol.
Volume: 20
Issue: 4
Pages: 511-35
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] 補体の沈着を認めなかったPLA2R陽性特発性膜性腎症の1例2016
Author(s)
藤岡 啓介, 清水 真樹, 伊藤 敏恭, 竹廣 敏史, 市原 朋子, 藤井 笑子, 坂口 善市, 木下 ゆき子, 漆原 真樹, 近藤 秀治, 香美 祥二, 幸山 洋子
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Journal Title
日本小児腎臓病学会雑誌
Volume: 29
Pages: 33-38
NAID
Related Report
Peer Reviewed
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[Journal Article] The first nationwide survey and genetic analyses of Bardet-Biedl syndrome in Japan2015
Author(s)
Hirano M, Satake W, Ihara K, Tsug I, Kondo S, Saida K, Betsui H, Okubo K, Sakamoto H, Ueno S, Ikuno Y, Ishihara R, Iwahashi H, Ohishi M, Mano T, Yamashita T, Suzuki Y, Nakamura Y, Kusunoki S, Toda T
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Journal Title
PLOS ONE
Volume: 10
Issue: 9
Pages: e0136317-e0136317
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: general therapy2015
Author(s)
Kaku Y, Ohtsuka Y, Komatsu Y, Ohta T, Nagai T, Kaito H, Kondo S, Ikezumi Y, Tanaka S, Matsumoto S, Sako M, Tsuruga K, Nakanishi K, Kamei K, Saito H, Fujinaga S, Hamasaki Y, Chikamoto H, Ishikura K, Iijima K
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Journal Title
Clin Exp Nephrol
Volume: 19
Issue: 1
Pages: 34-53
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: medical therapy2015
Author(s)
Ishikura K, Matsumoto S, Sako M, Tsuruga K, Nakanishi K, Kamei K, Saito H, Fujinaga S, Hamasaki Y, Chikamoto H, Ohtsuka Y, Komatsu Y, Ohta T, Nagai T, Kaito H, Kondo S, Ikezumi Y, Tanaka S, Kaku Y, Iijima K
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Journal Title
Clin Exp Nephrol
Volume: 19
Issue: 1
Pages: 6-33
DOI
Related Report
Peer Reviewed
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[Presentation] 当院における百日咳28例の臨床的検討2016
Author(s)
岡田 隆文, 西村 恵子, 中村 直子, 藤原 由美, 近藤 秀治, 横田 一郎, 岩井 艶子, 岩井 朝幸, 伊藤 道徳
Organizer
第119回日本小児科学会学術集会
Place of Presentation
札幌
Year and Date
2016-05-13
Related Report
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[Presentation] 常染色体劣性多発性嚢胞腎(ARPKD)に巨大膵嚢胞を合併し、PD継続が困難であった2歳女児例2015
Author(s)
苗代 有鈴, 菅原 典子, 金子 直人, 薮内 智朗, 多田 憲正, 神田 祥一郎, 宮井 貴之, 石塚 喜世伸, 秋岡 祐子, 服部 元史, 世川 修, 近藤 秀治
Organizer
第60回日本透析医学会学術集会・総会
Place of Presentation
横浜市
Year and Date
2015-06-26
Related Report
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[Presentation] 補体の沈着を認めなかったPLA2R陽性膜性腎症の1例2015
Author(s)
藤岡 啓介, 清水 真樹, 伊藤 敏恭, 竹廣 敏史, 市原 朋子, 藤井 笑子, 坂口 善市, 幸山 洋子, 木下 ゆき子, 漆原 真樹, 近藤 秀治, 香美 祥二
Organizer
第50回日本小児腎臓病学会学術集会
Place of Presentation
神戸市
Year and Date
2015-06-18
Related Report
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[Presentation] 巨大膵嚢胞を認めた繊毛病の1例2015
Author(s)
苗代 有鈴, 神田 祥一朗, 金子 直人, 薮内 智朗, 多田 憲正, 菅原 典子, 宮井 貴之, 石塚 喜世伸, 近本 裕子, 秋岡 祐子, 世川 修, 三浦 健一郎, 張田 豊, 近藤 秀治, 香美 祥二, 服部 元史
Organizer
第50回日本小児腎臓病学会学術集会
Place of Presentation
神戸市
Year and Date
2015-06-18
Related Report
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