Analyses on the mechanisms underlying the perturbation of regulatory machinery of intrinsic cellular properties of neural progenitors by the suppressed level of maternally-derived taurine
| Project/Area Number |
26461629
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
Tochitani Shiro 福井大学, 子どものこころの発達研究センター, 特命助教 (90418591)
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| Co-Investigator(Kenkyū-buntansha) |
松崎 秀夫 福井大学, 子どものこころの発達研究センター, 教授 (00334970)
岩田 圭子 福井大学, 子どものこころの発達研究センター, 助教 (30415088)
福田 敦夫 浜松医科大学, 医学部, 教授 (50254272)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | タウリン / 神経発生 / 神経前駆細胞 / 層特異的神経細胞 / 胎盤 / 母体由来栄養 / 神経発達障害 / GABAA受容体 / 神経幹細胞 / 性質制御 / 大脳皮質背内側部 / 細胞分化 / タウリントランスポーター / 脳発達 / 大脳皮質 / GABA / 行動 |
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| Outline of Final Research Achievements |
Mammalian fetuses including humans have little ability to synthesize taurine. Therefore, fetuses are dependent on the taurine delivered via the placenta from their mothers. In this study, we examined whether fetal exposure to low taurine condition during pregnancy influences the brain development of offspring especially regarding the regulation of properties of neural progenitors, which differentiate into neurons. The results showed that the exposure to low taurine condition induced the delay in the onset of the differentiation of neural progenitors into neurons and the alterations in the cellular types of neurons that neural progenitors produce. The inhibition of the receptors of taurine in fetal brain during specific periods of brain development induced a considerable alteration in offspring behavior. These results suggest that the maternal low taurine condition during pregnancy hampers the healthy development of the fetal brain.
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Report
(4 results)
Research Products
(15 results)
