The verification of the fetal origins of adult disease theory using human iPS cell pancreatic differentiation system
| Project/Area Number |
26461638
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Embryonic/Neonatal medicine
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
shiraki nobuaki 東京工業大学, 生命理工学院, 准教授 (70448520)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | DOHaD / Barker説 / 生活習慣病胎児期発症説 / iPS / アミノ酸 / 分化 / barker仮説 / 膵臓分化 / 生活習慣病胎児期起源説 / メチオニン代謝 / iPS細胞 |
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| Outline of Final Research Achievements |
Low birth weight is strongly predictive of lifestyle related disease. Animal study indicated that fetal malnutrition induce fetuses with growth retardation have a decreased beta cell mass, which persists into adulthood and causes glucose intolerance. However, The verification of this malnutrition’s effect on human fetuses was difficult. The aim of this study is checking the effect of fetal malnutrition on human using human iPS cell pancreatic differentiation methods. In this study, I have found that important amino acids which regulate pancreatic differentiation at narrow time windows using novel pancreatic differentiation methods established in this study. As a results of amino acid deprivation during pancreatic endocrine differentiation, the number of pancreatic beta cell is significantly decreased at final stage. These results indicated that iPS cell differentiation systems is useful tools for analysis of fetal origins of adult disease theory.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells.2014
Author(s)
Shiraki, N., Shiraki, Y., Tsuyama, T., Obata, F., Miura, M., Nagae, G., Aburatani, H., Kume, K., Endo, F., and Kume, S.
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Journal Title
Cell Metab.
Volume: 19
Issue: 5
Pages: 780-794
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] 多能性幹細胞におけるメチオニン代謝の役割2014
Author(s)
白木 伸明, 白木 恭子, 津山 友徳, 小幡 史明, 三浦 正幸, 永江 玄太, 油谷 浩幸, 粂 和彦, 遠藤 文夫, 粂 昭苑
Organizer
日本アミノ酸学会 第8回学術大会
Place of Presentation
東京農業大学世田谷キャンパス
Year and Date
2014-10-09
Related Report
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