Functional analysis of suicide-related genes in brain
Project/Area Number |
26461718
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Psychiatric science
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Research Institution | Kobe University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
曽良 一郎 神戸大学, 医学研究科, 教授 (40322713)
泉 剛 北海道大学, 医学研究科, 准教授 (60312360)
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Co-Investigator(Renkei-kenkyūsha) |
Watanabe Masahiko 北海道大学, 医学研究科, 教授 (70210945)
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Research Collaborator |
Kusumi Ichiro 北海道大学, 医学研究科, 教授 (30250426)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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Keywords | 自殺 / GWAS / 動物モデル / 神経幹細胞 / 自殺の生物学 / ゲノムワイド関連研究 / 神経前駆細胞 / SNP / うつ病 |
Outline of Final Research Achievements |
The genetic research of complete suicide is behind other mental problems because it is extremely difficult to obtain tissue samples of completed suicide. Under the difficult situation, we performed a GWAS using 500 samples of suicide completers, and found two candidates of suicide-related gene; PTCHD3 and RAB18. Here, we investigated the function of these candidate genes in chronic stressed rats and mouse neural stem cells. Stressed rats showed higher PTCHD3 expression in prefrontal cortex and hippocampus, and lower RAB18 expression in amygdala. In mouse neural stem cells with RAB18 knockdown, cell proliferation and survival were significantly increased compared to controls. Our results suggest aberrant expression of these suicide-related genes may be associated with brain abnormalities in stress conditons. Replication GWAS of suicide completers and further in vivo and in vitro analyses are needed in future studies.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Association study of MIF promoter polymorphisms with suicide completers in the Japanese population2017
Author(s)
Naofumi Shimmyo, Akitoyo Hishimoto, Ikuo Otsuka, Satoshi Okazaki, Shuken Boku, Kentaro Mouri, Tadasu Horai, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora
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Journal Title
Neuropsychiatric Disease and Treatment
Volume: 13
Pages: 899-908
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Aberrant telomere length and mitochondrial DNA copy number in suicide completers2017
Author(s)
Ikuo Otsuka, Takeshi Izumi, Shuken Boku, Atsushi Kimura, Yuan Zhang, Kentaro Mouri, Satoshi Okazaki, Kyoichi Shiroiwa, Motonori Takahashi, Yasuhiro Ueno, Osamu Shirakawa, Ichiro Sora, Akitoyo Hishimoto
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Journal Title
Scientific Reports
Volume: in press
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Rare truncating variations and risk of schizophrenia: Whole-exome sequencing in three families with affected siblings and a three-stage follow-up study in a Japanese population.2016
Author(s)
Watanabe Y, Nunokawa A, Shibuya M, Ikeda M, Hishimoto A, Kondo K, Egawa J, Kaneko N, Muratake T, Saito T, Okazaki S, Shimasaki A, Igeta H, Inoue E, Hoya S, Sugai T, Sora I, Iwata N, Someya T
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Journal Title
Psychiatry Research
Volume: 235
Pages: 13-18
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Association analysis of the HLA-DRB1*01 and HLA-DRB1*04 with schizophrenia by tag SNP genotyping in the Japanese population.2015
Author(s)
Ratta-apha W, Boku S, Mouri K, Okazaki S, Otsuka I, Watanabe Y, Nunokawa A, Someya T, Shirakawa O, Sora I, Hishimoto A.
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Journal Title
Psychiatry Res.
Volume: 229
Issue: 1-2
Pages: 627-628
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Assessment of copy number variations in the brain genome of schizophrenia patients.2015
Author(s)
Sakai M, Watanabe Y, Someya T, Araki K, Shibuya M, Niizato K, Oshima K, Kunii Y, Yabe H, Matsumoto J, Wada A, Hino M, Hashimoto T, Hishimoto A, Kitamura N, Iritani S, Shirakawa O, Maeda K, Miyashita A, Niwa S, Takahashi H, Kakita A, Kuwano R, Nawa H.
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Journal Title
Mol Cytogenet.
Volume: 8
Issue: 1
Pages: 46-46
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association analysis of the Cadherin13 gene with schizophrenia in the Japanese population.2015
Author(s)
Otsuka I, Watanabe Y, Hishimoto A, Boku S, Mouri K, Shiroiwa K, Okazaki S, Nunokawa A, Shirakawa O, Someya T, Sora I.
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Journal Title
Neuropsychiatr Dis Treat.
Volume: 11
Pages: 1381-1393
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Blood Diagnostic Biomarkers for Major Depressive Disorder using Multiplex DNA Methylation Profiles: Discovery and Validation.2015
Author(s)
Shusuke Numata, Kazuo Ishii, Atsushi Tajima, Jun-Ichi Iga, Makoto Kinoshita, Shinya Watanabe, Hidehiro Umehara, Manabu Fuchikami, Satoshi Okada, Shuken Boku, Akitoyo Hishimoto, Shinji Shimodera, Issei Imoto, Shigeru Morinobu, Tetsuro Ohmori
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Journal Title
Epigenetics
Volume: 10(2)
Issue: 2
Pages: 135-141
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A rare MIR138-2 gene variation is associated with schizophrenia in a Japanese population2014
Author(s)
Watanabe, Y., Hishimoto, A., Shibuya, M., Nunokawa, A., Kaneko, N., Igeta, Egawa, J., Mouri, K., Sora, I., Someya, T.
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Journal Title
Psychiatry Research
Volume: 215
Issue: 3
Pages: 801-802
DOI
Related Report
Peer Reviewed
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[Journal Article] Association analysis of putative cis-acting polymorphisms of interleukin-19 gene with schizophrenia2014
Author(s)
Okazaki, S., Watanabe, Y., Hishimoto, A., Sasada, T., Mouri, K., Shiroiwa, K., Eguchi, N., Ratta-Apha, W., Otsuka, I., Nunokawa, A., Kaneko, N., Shibnuya. M., Someya, T., Shirakawa, O., Sora, I.
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Journal Title
Progress in Neuro-Psychopharmacology & Biological Psychiatry
Volume: 50
Pages: 151-156
DOI
Related Report
Peer Reviewed
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[Journal Article] Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers.2014
Author(s)
Ratta-Apha W, Hishimoto A, Mouri K, Shiroiwa K, Sasada T, Yoshida M, Okazaki S, Supriyanto I, Asano M, Ueno Y, Shirakawa O, Sora I
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Journal Title
Psychiatry Res
Volume: 215
Issue: 1
Pages: 249-251
DOI
Related Report
Peer Reviewed
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