| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Glutamate (Glu) and Glutamine (Gln) were separated and quantitated for bipolar disorder patients and healthy control subjects using high magnetic field MRS. Pearson 's correlation analysis revealed a significant positive correlation between the lithium carbonate blood concentration and the Gln / Glu ratio in the left basal ganglia, the valproate blood concentration and Glu in the anterior cingulate gyrus. Considering the influence of these drugs, the ratio of Gln / Glu was increased in the anterior cingulate gyrus in patients with bipolar disorder. The separation and quantification of GABA was also performed, but no clear drug effect was observed.
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