Genetic analysis of a large family with schizophrenia adopting ARMS and developmental disorder traits as intermediate phenotypes
| Project/Area Number |
26461721
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Psychiatric science
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| Research Institution | Nagasaki University |
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Principal Investigator |
IMAMURA Akira 長崎大学, 病院(医学系), 教授 (40325642)
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| Co-Investigator(Kenkyū-buntansha) |
吉浦 孝一郎 長崎大学, 原爆後障害医療研究所, 教授 (00304931)
黒滝 直弘 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (20423634)
小澤 寛樹 長崎大学, 医歯薬学総合研究科(医学系), 教授 (50260766)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 統合失調症 / 大家系 / ARMS / 発達障害 / 自閉スペクトラム症 / 家系研究 / 次世代シーケンサー / 神経発達症群 |
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| Outline of Final Research Achievements |
With the purpose of identifying rare risk variants for schizophrenia, we conducted a genetic analysis of a large family including many individuals with schizophrenia. Whole-exome analysis was performed in 10 individuals from this family. Target sequencing of two identified candidate genes was also performed in 288 individuals with schizophrenia and 419 healthy controls, narrowing the candidate gene pool to only gene A. In a behavioral analysis conducted using Gene A knock-in mice created using Crispr-cas9 technology, the genetically modified mice exhibited decreased activity or attenuated motor function.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Whole-exome sequencing and gene-based rare variant association tests suggest that PLA2G4E might be a risk gene for panic disorder. Transl Psychiatry.2018
Author(s)
Morimoto Y, Shimada-Sugimoto M, Otowa T, Yoshida S, Kinoshita A, Mishima H, Yamaguchi N, Mori T, Imamura A, Ozawa H, Kurotaki N, Ziegler C, Domschke K, Deckert J, Umekage T, Tochigi M, Kaiya H, Okazaki Y, Tokunaga K, Sasaki T, Yoshiura KI, Ono S.
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Journal Title
Transl Psychiatry
Volume: 8
Issue: 1
Pages: 41-41
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] De novo non-synonymous TBL1XR1 mutation alters Wnt signaling activity2017
Author(s)
Nishi Akira、Numata Shusuke、Tajima Atsushi、Zhu Xiaolei、Ito Koki、Saito Atsushi、Kato Yusuke、Kinoshita Makoto、Shimodera Shinji、Ono Shinji、Ochi Shinichiro、Imamura Akira、Kurotaki Naohiro、Ueno Shu-ichi、Iwata Nakao、Fukui Kiyoshi、Imoto Issei、Kamiya Atsushi、Ohmori Tetsuro
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Journal Title
Scientific Reports
Volume: 7
Issue: 1
Pages: 2887-2887
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Characteristics of Inattention and Hyperactivity, Perception of General Health, and Reading Literacy of Japanese Adolescents: Results from a Large-scale Community Sample,2017
Author(s)
Yamada S, Imamura A, Honda S, Iwanaga R, Shibuya K, Winnie D, Ozawa H,
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Journal Title
Acta medica Nagasakiensia
Volume: 61
Pages: 71-79
NAID
Related Report
Peer Reviewed
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[Journal Article] Differential impacts of duration of untreated psychosis (DUP) on cognitive function in first-episode schizophrenia according to mode of onset2015
Author(s)
Shinya Ito, Takahiro Nemoto, Naohisa Tsujino, Noriyuki Ohmuro, Kazunori Matsumoto, Hiroo Matsuoka, Kodai Tanaka, Shimako Nishiyama, Michio Suzuki, Hirohisa Kinoshita, Hiroki Ozawa, Hirokazu Fujita, Shinji Shimodera, Toshifumi Kishimoto, Kunichika Matsumoto, Tomonori Hasegawa, Masafumi Mizuno
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Journal Title
European Psychiatry
Volume: 30
Issue: 8
Pages: 995-1001
DOI
Related Report
Peer Reviewed
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