| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
With the purpose of identifying rare risk variants for schizophrenia, we conducted a genetic analysis of a large family including many individuals with schizophrenia. Whole-exome analysis was performed in 10 individuals from this family. Target sequencing of two identified candidate genes was also performed in 288 individuals with schizophrenia and 419 healthy controls, narrowing the candidate gene pool to only gene A. In a behavioral analysis conducted using Gene A knock-in mice created using Crispr-cas9 technology, the genetically modified mice exhibited decreased activity or attenuated motor function.
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