Search for the candidate genes for mental and developmental disorders by analyzing family and discordant twin samples

• Project/Area Number: 26461725
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Teikyo University
• Principal Investigator: Tochigi Mamoru 帝京大学, 医学部, 准教授 (40456116)
• Co-Investigator(Kenkyū-buntansha): 桑原 斉 東京大学, バリアフリー支援室, 准教授 (50456117) ; 垣内 千尋 東京大学, 医学部附属病院, 准教授 (90342766)
• Research Collaborator: SASAKI Tsukasa ; IKEBUCHI Emi ; AKAHANE Akihisa
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 精神疾患 / 発達障害 / 候補遺伝子 / 多発家系 / 一卵性双生児

Outline of Final Research Achievements

We collected the DNA samples of the family, sporadic, and discordant twin patients of mental and developmental　disorders,　including　schizophrenia,　bipolar　disorder,　panic　disorder,　autism,　and　Tourette　disorder. Through analyzing exome sequencing by using next-generation sequencer and microarray, the several candidate genes were collected for schizophrenia and Tourette disorder.

Research Products

• [Presentation] Evaluating detected rare variants of glycine cleavage system genes in schizophrenia with metabolomics profilings (2014)
  • Author(s): Yoshikawa A, Nishimura F, Tochigi M, Kawamura Y, Umekage T, Kato K, Sasaki T, Ohashi Y, Iwamoto K, Kasai K, Kakiuchi C
  • Organizer: XXII World Congress on Psychiatric Genetics
  • Place of Presentation: Copenhagen
  • Year and Date: 2014-10-12 – 2014-10-16
• [Presentation] Targeted re-sequencing of SLITRK1 in Japanese patients with Tourette syndrome using next-generation sequencing (2014)
  • Author(s): Inai A, Kuwabara H, Nishimura F, Kato K, Yousuke E, Shimada T, Furukawa M, Sasaki T, Tochigi M, Kakiuchi C, Kasai K, Kano Y
  • Organizer: XXII World Congress on Psychiatric Genetics
  • Place of Presentation: Copenhagen
  • Year and Date: 2014-10-12 – 2014-10-16
• [Presentation] 統合失調症病態におけるNMDA受容体スイッチング制御因子の遺伝学的検討 (2014)
  • Author(s): 吉川茜、西村文親、稲井彩、西岡将基、江里口洋介、高屋淳彦、栃木衛、河村代志也、梅景正、加藤佳代子、佐々木司、笠井清登、垣内千尋
  • Organizer: 第36回日本生物学的精神医学会年会
  • Place of Presentation: 奈良
  • Year and Date: 2014-09-29 – 2014-10-01