Evaluation of x-ray detectors for micro-angiography system using synchrotron radiation

• Project/Area Number: 26461813
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: High Energy Accelerator Research Organization
• Principal Investigator: HYODO KAZUYUKI 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 准教授 (60201729)
• Co-Investigator(Kenkyū-buntansha): 松下 昌之助 筑波技術大学, 保健科学部, 教授 (70359579)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 放射光 / 放射光単色X線 / 微小血管造影 / X線光学素子 / 非対称反射 / X線検出器 / 血管造影剤 / X線イメージング / 空間分解能 / 濃度分解能 / Ｘ線検出器 / 造影剤 / 単色Ｘ線 / 画像処理 / 単色X線

Outline of Final Research Achievements

Micro-angiography using synchrotron radiation monochromatic X-rays, which X-ray energy is above the K-edge of Iodine, allows us to evaluate small vessels of less than 100 microns in diameter. The purpose of this study was to evaluate the performance of micro-angiography system using new two-dimensional X-ray detectors. The results demonstrate the effectiveness of micro-angiography for visualizing the target vessels in an in-vivo rat.

Research Products

• [Journal Article] A new method for visualizing pulmonary artery microvasculature using synchrotron radiation pulmonary microangiography. -The measurement of pulmonary arterial blood flow velocity in the high pulmonary blood flow rat model-. (2018)
  • Author(s): Tokunaga C, Matsushita S, Hyodo K, Sakamoto H, Tanioka K, Miyakawa K, Kubota M, Hiramatsu Y.
  • Journal Title: Acta Radiologica Volume: 印刷中 Issue: 12 Pages: 1482-1486
  • DOI: 10.1177/0284185118770892
  • Peer Reviewed
• [Journal Article] Renal contrast microangiography with synchrotron radiation: a novel method for visualizing structures within nephrons in vivo. (2016)
  • Author(s): Miya K, Matsushita S, Hyodo K, Tokunaga C, Sakamoto H, Mizutani T, Hiramatsu Y.
  • Journal Title: Acta Radiologica Volume: 58 Issue: 4 Pages: 505-510
  • DOI: 10.1177/0284185116658685
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between endothelial function and micro-vascular remodeling measured by synchrotron radiation pulmonary micro-angiography in pulmonary arterial hypertension. (2016)
  • Author(s): uji S, Matsushita S, Hyodo K, Osaka M, Sakamoto H, Tanioka K, Miyakawa K, Kubota M, Hiramatsu Y, Tokunaga C.
  • Journal Title: General Thoracic and Cardiovascular Suregery Volume: 64 Issue: 10 Pages: 597-603
  • DOI: 10.1007/s11748-016-0684-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A new technique of in vivo synchrotron radiation coronary microangiography in the rat. (2015)
  • Author(s): Sakamoto H, Matsushita S, Hyodo K, Tokunaga C, Sato F, Hiramatsu Y
  • Journal Title: Acta Radiologica Volume: 未定
  • Peer Reviewed
• [Presentation] 縦偏光放射光を用いた医学イメージングシステムに関する基礎的検討 (2018)
  • Author(s): 亀沢知夏、兵藤一行
  • Organizer: 2017年度量子ビームサイエンスフェスタ
• [Presentation] KEK放射光医学X線イメージング実験ステーションの現状 (2018)
  • Author(s): 兵藤一行
  • Organizer: 第3回TIA光・量子計測シンポジウム
• [Presentation] 放射光単色Ｘ線の医学イメージング応用 (2017)
  • Author(s): 兵藤一行
  • Organizer: ICT時代の手術の進化ワークショップ
  • Place of Presentation: 筑波大学（茨城県つくば市）
  • Year and Date: 2017-01-28
• [Presentation] 放射光単色X線を用いた医学イメージングシステムの開発 (2017)
  • Author(s): 兵藤一行
  • Organizer: 筑波大－KEK連携セミナー
• [Presentation] 可視不能な体内植え込み型医療機器のリアルタイム可視化装置の開発ー放射光の利用に関する考察 (2016)
  • Author(s): 兵藤一行、河田 洋、鶴嶋英夫、豊川弘之
  • Organizer: 第2回TIA光・量子計測シンポジウム
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Year and Date: 2016-11-10
• [Presentation] Medical applications at beamlines, BL-14C and NE7A, at the Photon Factory (2016)
  • Author(s): Hyodo K and Ando M
  • Organizer: The 11th Asian Meeting on Synchrotron Radiation Biomedical Imaging
  • Place of Presentation: Pyeongchang (Korea)
  • Year and Date: 2016-10-07
  • Int'l Joint Research
• [Presentation] 放射光単色Ｘ線を用いた医学診断用イメージングシステムの開発 (2016)
  • Author(s): 兵藤一行
  • Organizer: 筑波大学 医療系-理工 情報交換ミーティング
  • Place of Presentation: 筑波大学（茨城県つくば市）
  • Year and Date: 2016-05-27
• [Presentation] Recent Status of the Photon Factory and a Future Program (2016)
  • Author(s): Hyodo K
  • Organizer: Workshop of the 10th Asian Meeting on Synchrotron Radiation Biomedical Imaging
  • Place of Presentation: 山形医学交流会館（山形県山形市）
  • Year and Date: 2016-02-19
  • Int'l Joint Research
• [Presentation] 微小血管系診断システムに関する基礎的特性評価 (2016)
  • Author(s): 兵藤一行、松下昌之助
  • Organizer: 第２９回日本放射光学会年会・放射光科学合同シンポジウム
  • Place of Presentation: 柏の葉カンファレンスセンター（千葉県柏市）
  • Year and Date: 2016-01-09
• [Presentation] A Novel Method of Synchrotron Radiation Renal Microangiography (2015)
  • Author(s): Miya K, Matsushita S, Hyodo K, Tokunaga C, Sakamoto H, Mizutani T, Hiramatsu Y
  • Organizer: Medical Applications of Synchrotron Radiation 2015
  • Place of Presentation: Villard de Lans, France
  • Year and Date: 2015-10-05
  • Int'l Joint Research
• [Presentation] PFにおける放射光単色X線を用いた血管系診断システムの開発 (2015)
  • Author(s): 兵藤一行、松下昌之助、鶴嶋英夫、松村 明
  • Organizer: 第１回光・量子計測シンポジウム
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Year and Date: 2015-09-09
• [Presentation] 放射光による腎微小血管造影 (2015)
  • Author(s): 宮、松下、兵藤、徳永、坂本、水谷、平松
  • Organizer: 第３回物構研サイエンスフェスタ
  • Place of Presentation: つくば国際会議場（茨城県つくば市）
  • Year and Date: 2015-03-17 – 2015-03-18