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New therapy for primary aldosteronism: Adrenal obliteration by balloon-occluded retrograde venous ethanol injection in swine model

Research Project

Project/Area Number 26461849
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionShiga University of Medical Science

Principal Investigator

Ota Shinichi  滋賀医科大学, 医学部, 講師 (30583637)

Co-Investigator(Kenkyū-buntansha) 新田 哲久  滋賀医科大学, 医学部, 准教授 (40324587)
園田 明永  滋賀医科大学, 医学部, 助教 (00571051)
渡邉 尚武  滋賀医科大学, 医学部, 特任助教 (60570364)
友澤 裕樹  滋賀医科大学, 医学部, 助教 (90585689)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords副腎静脈塞栓術 / エタノール / バルーン閉塞下 / 副腎静脈梗塞 / 原発性アルドステロン症
Outline of Final Research Achievements

Transarterial embolization (TAE) are less invasive procedures for adrenal neoplasms. However, it is sometimes difficult to select the appropriate feeding arteries in TAE. It is relatively easy for the interventional radiologists who are familiar with adrenal venous sampling (AVS) to select the bilateral adrenal veins. Therefore, venous approach is feasible to obliterate the adrenal gland. Absolute ethanol is the most appropriate embolic agent for balloon occluded adrenal venous embolization owing to effective results in histopathological and angiographic evaluation.
Moreover, we evaluated the changes over time and effects of balloon occluded adrenal venous embolization using absolute ethanol in order to review MRI findings, histopathological findings and hormonal examinations. Then, balloon occluded adrenal venous embolization using absolute ethanol caused partial adrenal hemorrhagic infarction and it was one of procedure to cause adrenal obliteration.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Adrenal obliteration by balloon-occluded retrograde venous ethanol injection in swine model2017

    • Author(s)
      Akitoshi Inoue, Shinichi Ohta, Norihisa Nitta, Shizuka Tsuboi, Akinaga Sonoda, Yuki Tomozawa, Shobu Watanabe, Kenichi Mukaisho, Kiyoshi Murata,
    • Journal Title

      Minimally Invasive Therapy & Allied Technologies

      Volume: 26

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Adrenal obliteration by balloon-occluded retrograde venous ethanol injection in swine model2017

    • Author(s)
      Akitoshi Inoue, Shinichi Ohta, Norihisa Nitta, Shizuka Tsuboi, Akinaga Sonoda, Yuki Tomozawa, Shobu Watanabe, Kenichi Mukaisho, Kiyoshi Murata
    • Organizer
      Asian Congress of Abdominal Radiology 2017
    • Place of Presentation
      Busan, Korea
    • Year and Date
      2017-04-21
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] バルーン閉塞下副腎静脈塞栓術に用いる塞栓物質の基礎研究2016

    • Author(s)
      井上明星、大田信一、新田哲久、坪居穏佳、上村諒、田上佳英、今井勇伍、高木海、中川達也、友澤裕樹、渡辺尚武、瀬古安由美、園田明永、村田喜代史、向所賢一
    • Organizer
      第45回日本IVR学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 無水エタノールを用いたバルーン閉塞下副腎静脈塞栓術の基礎的研究2016

    • Author(s)
      井上明星、大田信一、新田哲久、坪居穏佳、上村諒、田上佳英、今井勇伍、高木海、中川達也、友澤裕樹、渡辺尚武、瀬古安由美、園田明永、村田喜代史、向所賢一
    • Organizer
      第45回日本IVR学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] バルーン閉塞下副腎静脈塞栓術に用いる塞栓物質の基礎的研究2016

    • Author(s)
      井上明星
    • Organizer
      第45回日本IVR学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル
    • Year and Date
      2016-05-27
    • Related Report
      2015 Research-status Report
  • [Presentation] 無水エタノールを用いたバルーン閉塞下副腎静脈塞栓術の基礎的研究2016

    • Author(s)
      井上明星
    • Organizer
      第45回日本IVR学会総会
    • Place of Presentation
      ウェスティンナゴヤキャッスル
    • Year and Date
      2016-05-27
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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