Development of radiosensitizers based on antitumor/molecular targeted drugs modified by acetylglucose

• Project/Area Number: 26461891
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: The University of Tokushima
• Principal Investigator: Uto Yoshihiro 徳島大学, 大学院生物資源産業学研究部, 教授 (20304553)
• Co-Investigator(Renkei-kenkyūsha): ENDO YOSHIO 金沢大学, がん進展制御研究所, 准教授 (30211783) ; TOMINAGA MASAHIDE 徳島大学, 大学院医歯薬学研究部, 助教 (90437632)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 放射線増感剤 / アセチルグルコース修飾ゲフィチニブ / 分子標的薬剤 / EGFR / アセチル化グルコース / アセチルグルコース修飾放射線増感剤

Outline of Final Research Achievements

The aim of this study is that development of clinical usage radiosensitizers based on acetylglucose-modified antitumor and molecular targeted drug using a tumor cell and a tumor-bearing chicken egg model. In this study, we succeeded in develop of new radiosensitizer UTX-103 which modified acetylglucose to the Gefitinib as an antitumor agent which inhibited the tyrosine kinase of the epidermal growth factor receptor selectively.

Research Products

• [Journal Article] Radiosensitivity uncertainty evaluation for the in vitro biophysical modeling of EMT6 cells. (2014)
  • Author(s): Oita M, Uto Y, Tominaga M, Sasaki M, Hara Y, Kishi T, Hori H.
  • Journal Title: Anticancer Research Volume: 34 Pages: 4621-4626
  • Peer Reviewed
• [Presentation] Development of Sugar-modified Radiosensitizer (TX-2244) Targeting the Glycolytic Metabolism of Tumors (2017)
  • Author(s): 宮本 大輔，篠原 侑成，八重 和憲，上 﨑 里砂，羽生 紋佳，山田 久嗣，富永 正英，宇都 義浩
  • Organizer: 日本化学会第97春季年会
  • Place of Presentation: 慶應義塾大学日吉キャンパス（神奈川県横浜市）
  • Year and Date: 2017-03-16
• [Presentation] TrueBeamを用いた低LET放射線の線量率と生物効果の相関について (2016)
  • Author(s): 宇都 義浩, 遠藤 秀彰, 八重 和憲, 山田 久嗣, 原 毅弘, 富永 正英
  • Organizer: 第18回癌治療増感研究シンポジウム
  • Place of Presentation: 奈良
  • Year and Date: 2016-02-05
• [Presentation] 放射線増感ユニットとしてのアセチルグルコースの有用性： アセチルグルコース修飾Gefitinib誘導体の分子設計および放射線増感効果について (2016)
  • Author(s): 宇都 義浩，伊藤亮輔，八重和憲，宮本大輔，上崎里砂，山田久嗣，富永正英
  • Organizer: 第22回癌治療増感研究会
  • Place of Presentation: 沖縄県市町村自治会館（沖縄県那覇市）
• [Presentation] The effect of dose rate on radiation-induced in vitro antitumor activity by low-LET radiation (2015)
  • Author(s): Takehiro Hara, Masahide Tominaga, Hideaki Endo and Yoshihiro Uto
  • Organizer: 15th International Congress of Radiation Research
  • Place of Presentation: 京都
  • Year and Date: 2015-05-25
  • Int'l Joint Research