| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Cancer associated fibroblasts (CAFs) play a crucial role for tumor progression in a variety of malignancy. Activated CAFs frequently express α-smooth muscle actin(SMA) and are classified as myofibroblasts. However, the role and significance of CAFs in gastric cancer progression is still unknown. We investigated the biology of CAFs in human gastric cancers, in particular scirrhous gastric cancer characterized by intense stromal fibroblasts.
We demonstrated that the CAFs in primary site of scirrhous gastric cancer are composed of HGF-producing and both SMA- and fibroblast activation protein (FAP)- expressing activated fibroblasts. Thus, targeting marked HGF production in SMA+ and FAP+ CAFs of scirrhous gastric cancer may result in a clinically effective reduction of tumor progression and dissemination.
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