Relation of P-cadherin and Rho family in intrahepatic cholangiocarcinoma
Project/Area Number |
26462045
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Kumamoto University |
Principal Investigator |
HORINO Kei 熊本大学, 医学部附属病院, 非常勤診療医師 (60452900)
|
Co-Investigator(Kenkyū-buntansha) |
今井 克憲 熊本大学, 医学部附属病院, 助教 (60555746)
別府 透 熊本大学, 医学部附属病院, 非常勤診療医師 (70301372)
林 洋光 熊本大学, 医学部附属病院, 非常勤診療医師 (80625773)
|
Research Collaborator |
SAKAMOTO Keita 熊本大学, 医学部附属病院, 非常勤診療医師
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | P-cadherin / methylation / unmethylation / promoter / invasion / migration / Rho family / Akt/Ark signal / CDH3 / rho family / methylatiom |
Outline of Final Research Achievements |
P-cadherin overexpression may serve as a useful biomarker of invasive phenotype and poor prognosis. P-cadherin expression was found to be regulated by its promoter methylation. These results suggest that P-cadherin represents a novel therapeutic target for the treatment of intrahepatic cholangiocarcinoma and pancreatic cancer. However, how P-cadherin affects tumor behavior is still unclear. There is a discrepancy in its role between different cancer types. We should continue a study of mechanism caused by P-cadherin overexpression.
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Report
(4 results)
Research Products
(3 results)
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[Journal Article] Significance of P-cadherin overexpression and possible mechanism of its regulation in intrahepatic cholangiocarcinoma and pancreatic cancer.2015
Author(s)
1.Keita Sakamoto, Katsunori Imai, Takaaki Higashi, Katunobu Taki, Shigeki Nakagawa, Hirohisa Okabe, Hidetoshi Nitta, Hiromitsu Hayashi, Akira Chikamoto, Takatoshi Ishiko, Toru Beppu and Hideo Baba.
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Journal Title
Cancer Sci
Volume: 106(9)
Pages: 1153-62
DOI
Related Report
Peer Reviewed
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