Possibility of a prevention or therapeutic drug for the cerebral vasospasm after subarachnoid hemorrhage

• Project/Area Number: 26462156
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurosurgery
• Research Institution: Shinshu University
• Principal Investigator: MORO Makoto 信州大学, 医学部附属病院, 特任研究員 (90648651)
• Co-Investigator(Kenkyū-buntansha): 村田 貴弘 信州大学, 医学部附属病院, 特任研究員 (80533322)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: くも膜下出血 / 脳血管攣縮 / β-アドレナリン受容体 / 血管弛緩 / 血管拡張

Outline of Final Research Achievements

We investigated the relaxant effects of β-adrenoceptor agonist on isolated rabbit basilar artery. As a result, β-adrenoceptor agonists including ritodrine hydrochloride dose-dependently relaxed on KCl-induced contraction of rabbit basilar artery.
Thereafter, we examined the messenger RNAs (mRNAs) expression of β-adorenoceptor on rabbit, dog and human basilar artery. The mRNA of β1 and β2-　adrenoceptor were detected on these basilar arteries .The in vivo pharmacological properties were tested, the effect of ritodrine hydrochloride on subarachnoid hemorrhage - induced cerebral vasospasm dog model. However, ritodrine hydrochloride did not improve this vasospasm.